Probable proton-coupled zinc antiporter SLC30A4

BE0009886ProteinHumansSLC30A4

Probable proton-coupled zinc ion antiporter mediating zinc import from cytoplasm potentially into the endocytic compartment (PubMed:19521526). It is acted on by 2 drugs in DrugBank.

Gene name
SLC30A4
UniProtKB entry
O14863Swiss-Prot
Cellular location
Endosome membrane
Residues / weight
429 residues · 47,482 Da
Also known as
Solute carrier family 30 member 4 · Zinc transporter 4 · ZnT-4 · ZNT4

Resolves to

Protein
UniProtO14863UniProt nameZNT4_HUMAN
Gene
HGNCHGNC:11015NCBI Gene7782GeneCardsSLC30A4
Pharmacology
KEGGhsa:7782
Structure
PDB9JJ3
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Probable proton-coupled zinc antiporter SLC30A4, how selective are they, and which programs against it are still in active trials?

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