Zinc transporter ZIP5

BE0009888ProteinHumansSLC39A5

Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine by the uptake of zinc from the blood... It is acted on by 2 drugs in DrugBank.

Gene name
SLC39A5
UniProtKB entry
Q6ZMH5Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
540 residues · 56,460 Da
Also known as
Solute carrier family 39 member 5 · ZIP-5 · ZIP5 · Zrt- and Irt-like protein 5

Resolves to

Protein
UniProtQ6ZMH5UniProt nameS39A5_HUMAN
Gene
HGNCHGNC:20502NCBI Gene283375GeneCardsSLC39A5
Pharmacology
KEGGhsa:283375
Structure
PDB7Y9CPDB7YF2PDB7YF4
Drugs

What you can answer from here — as of April 13, 2020

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Zinc transporter ZIP5, how selective are they, and which programs against it are still in active trials?

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