Zinc transporter ZIP2

Details

Name
Zinc transporter ZIP2
Kind
protein
Synonyms
  • 6A1
  • Eti-1
  • hZIP2
  • Solute carrier family 39 member 2
  • ZIP-2
  • ZIP2
  • Zrt- and Irt-like protein 2
Gene Name
SLC39A2
UniProtKB Entry
Q9NP94Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0052341|Zinc transporter ZIP2
MEQLLGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHHRLVLRLLGCISAGVFLGAG
FMHMTAEALEEIESQIQKFMVQNRSASERNSSGDADSAHMEYPYGELIISLGFFFVFFLE
SLALQCCPGAAGGSTVQDEEWGGAHIFELHSHGHLPSPSKGPLRALVLLLSLSFHSVFEG
LAVGLQPTVAATVQLCLAVLAHKGLVVFGVGMRLVHLGTSSRWAVFSILLLALMSPLGLA
VGLAVTGGDSEGGRGLAQAVLEGVAAGTFLYVTFLEILPRELASPEAPLAKWSCVAAGFA
FMAFIALWA
Number of residues
309
Molecular Weight
32742.03
Theoretical pI
Not Available
GO Classification
Functions
metal ion transmembrane transporter activity
Processes
cadmium ion transmembrane transport / keratinocyte differentiation
General Function
Transporter for the divalent cation Zn(2+) (PubMed:10681536, PubMed:29791142, PubMed:30914478). Mediates the influx of Zn(2+) into cells from extracellular space. The Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential. Transports also other divalent cations Zn(2+), Cd2(+), Cu2(+), Co2(+) in the order of decreasing affinity, respectively (PubMed:29791142, PubMed:30914478). In the skin, aids in the differentiation of keratinocytes in the epidermis (By similarity)
Specific Function
Metal ion transmembrane transporter activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
9-29 47-67 104-124 165-185 190-210 225-245 259-279 289-309
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052342|Zinc transporter ZIP2 (SLC39A2)
ATGGAGCAACTACTAGGAATAAAACTTGGCTGCCTGTTTGCCCTGTTGGCTCTCACTCTG
GGCTGTGGCCTTACTCCCATCTGCTTCAAATGGTTCCAGATTGATGCAGCCAGAGGTCAT
CACCGGCTAGTCCTCAGACTCCTGGGCTGTATTTCTGCTGGTGTTTTCCTGGGAGCAGGG
TTCATGCATATGACTGCTGAAGCCCTGGAGGAAATTGAATCACAGATTCAGAAGTTCATG
GTGCAGAACAGATCAGCAAGTGAGAGAAATTCTTCTGGTGATGCTGATTCAGCTCATATG
GAGTATCCCTATGGAGAGCTCATCATCTCCCTGGGCTTCTTTTTTGTCTTCTTTTTGGAG
TCGCTGGCATTGCAGTGCTGTCCTGGGGCTGCTGGAGGATCGACAGTGCAGGACGAAGAA
TGGGGTGGGGCTCATATCTTCGAACTCCACAGCCATGGACATTTACCCTCACCCTCAAAG
GGTCCCCTCCGAGCCCTTGTCCTCTTGCTGTCACTCTCCTTTCACTCAGTGTTTGAAGGG
CTAGCTGTGGGGCTGCAGCCGACAGTAGCAGCTACCGTGCAGCTCTGCCTTGCTGTCCTG
GCTCATAAGGGGCTTGTGGTGTTTGGTGTAGGAATGCGGCTAGTGCATTTAGGTACCAGC
TCACGATGGGCAGTGTTCTCCATACTATTATTAGCTCTCATGTCCCCCCTGGGCCTAGCC
GTAGGGCTGGCTGTGACTGGAGGGGACTCTGAAGGAGGGCGGGGCTTAGCCCAGGCTGTG
TTAGAGGGTGTGGCAGCTGGTACCTTCCTGTATGTCACCTTCCTAGAAATTCTTCCACGG
GAGCTAGCTAGTCCTGAGGCCCCTCTAGCTAAGTGGAGCTGTGTAGCCGCTGGTTTTGCC
TTCATGGCCTTTATTGCCTTGTGGGCCTGA
Chromosome Location
14
Locus
14q11.2
External Identifiers
ResourceLink
UniProtKB IDQ9NP94
UniProtKB Entry NameS39A2_HUMAN
GeneCard IDSLC39A2
HGNC IDHGNC:17127
KEGG IDhsa:29986
NCBI Gene ID29986
General References
  1. Yamaguchi S: [Subtraction cloning of growth arrest inducible genes in normal human epithelial cells]. Kokubyo Gakkai Zasshi. 1995 Mar;62(1):78-93. doi: 10.5357/koubyou.62.78. [Article]
  2. Gaither LA, Eide DJ: Functional expression of the human hZIP2 zinc transporter. J Biol Chem. 2000 Feb 25;275(8):5560-4. doi: 10.1074/jbc.275.8.5560. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Bruls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Segurens B, Aniere F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Menard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufosse-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guerin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quetier F, Waterston R, Hood L, Weissenbach J: The DNA sequence and analysis of human chromosome 14. Nature. 2003 Feb 6;421(6923):601-7. Epub 2003 Jan 1. [Article]
  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Zinc chlorideapproved, investigationalunknowntransportersubstrateDetails
Zinc sulfate, unspecified formapproved, experimentalunknowntransportersubstrateDetails