Proton-coupled zinc antiporter SLC30A9, mitochondrial

BE0009890ProteinHumansSLC30A9

Mitochondrial proton-coupled zinc ion antiporter mediating the export of zinc from the mitochondria and involved in zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health (PubMed:28334855, PubMed:34397090, PubMed:34433664, PubMed:35614220). It is acted on by 2 drugs in DrugBank.

Gene name
SLC30A9
UniProtKB entry
Q6PML9Swiss-Prot
Cellular location
Mitochondrion membrane
Residues / weight
568 residues · 63,515 Da
Also known as
C4orf1 · HUEL · Human embryonic lung protein · Solute carrier family 30 member 9 · Zinc transporter 9

Resolves to

Protein
UniProtQ6PML9UniProt nameZNT9_HUMAN
Gene
HGNCHGNC:1329NCBI Gene10463GeneCardsSLC30A9
Pharmacology
KEGGhsa:10463
Structure
PDB2ENK
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proton-coupled zinc antiporter SLC30A9, mitochondrial, how selective are they, and which programs against it are still in active trials?

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