Proton-coupled zinc antiporter SLC30A1

BE0009891ProteinHumansSLC30A1

Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319, PubMed:33996761, PubMed:39422023, PubMed:39111308, PubMed:39390258). It is acted on by 2 drugs in DrugBank.

Gene name
SLC30A1
UniProtKB entry
Q9Y6M5Swiss-Prot
Cellular location
Cell membrane
Residues / weight
507 residues · 55,299 Da
Also known as
Solute carrier family 30 member 1 · Zinc transporter 1 · ZNT1

Resolves to

Protein
UniProtQ9Y6M5UniProt nameZNT1_HUMAN
Gene
HGNCHGNC:11012NCBI Gene7779GeneCardsSLC30A1
Pharmacology
KEGGhsa:7779
Structure
PDB8J2GPDB8XM6PDB8XMA
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proton-coupled zinc antiporter SLC30A1, how selective are they, and which programs against it are still in active trials?

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