Proton-coupled zinc antiporter SLC30A2

BE0009892ProteinHumansSLC30A2

Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. It is acted on by 2 drugs in DrugBank.

Gene name
SLC30A2
UniProtKB entry
Q9BRI3Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle membrane
Residues / weight
372 residues · 40,564 Da
Also known as
Solute carrier family 30 member 2 · Zinc transporter 2 · ZnT-2 · ZNT2

Resolves to

Protein
UniProtQ9BRI3UniProt nameZNT2_HUMAN
Gene
HGNCHGNC:11013NCBI Gene7780GeneCardsSLC30A2
Pharmacology
KEGGhsa:7780
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proton-coupled zinc antiporter SLC30A2, how selective are they, and which programs against it are still in active trials?

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