Zinc transporter SLC39A7

BE0009893ProteinHumansSLC39A7

Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (PubMed:14525538, PubMed:15705588, PubMed:28205653, PubMed:29980658). It is acted on by 2 drugs in DrugBank.

Gene name
SLC39A7
UniProtKB entry
Q92504Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
469 residues · 50,118 Da
Also known as
Histidine-rich membrane protein Ke4 · HKE4 · Really interesting new gene 5 protein · RING5 · Solute carrier family 39 member 7

Resolves to

Protein
UniProtQ92504UniProt nameS39A7_HUMAN
Gene
HGNCHGNC:4927NCBI Gene7922GeneCardsSLC39A7
Pharmacology
KEGGhsa:7922
Structure
PDB8GZE
Drugs

What you can answer from here — as of April 13, 2020

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Zinc transporter SLC39A7, how selective are they, and which programs against it are still in active trials?

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