Zinc transporter SLC39A7

Details

Name
Zinc transporter SLC39A7
Kind
protein
Synonyms
  • Histidine-rich membrane protein Ke4
  • HKE4
  • Really interesting new gene 5 protein
  • RING5
  • Solute carrier family 39 member 7
  • ZIP7
  • Zrt-, Irt-like protein 7
Gene Name
SLC39A7
UniProtKB Entry
Q92504Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0052349|Zinc transporter SLC39A7
MARGLGAPHWVAVGLLTWATLGLLVAGLGGHDDLHDDLQEDFHGHSHRHSHEDFHHGHSH
AHGHGHTHESIWHGHTHDHDHGHSHEDLHHGHSHGYSHESLYHRGHGHDHEHSHGGYGES
GAPGIKQDLDAVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGL
LGDAFLHLIPHALEPHSHHTLEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHV
KGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGP
VRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEV
PHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAVGSEIAGGAGPGWVL
PFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVIMMVLIAHLE
Number of residues
469
Molecular Weight
50117.95
Theoretical pI
Not Available
GO Classification
Functions
zinc ion transmembrane transporter activity
Processes
zinc ion transmembrane transport
Components
endoplasmic reticulum / endoplasmic reticulum membrane / Golgi apparatus / membrane / nucleoplasm
General Function
Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (PubMed:14525538, PubMed:15705588, PubMed:28205653, PubMed:29980658). Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation (PubMed:22317921, PubMed:28205653, PubMed:29980658). Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function (By similarity). Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in different biological contexts (PubMed:29980658, PubMed:30237509). Mediates Zn(2+)-induced ferroptosis (PubMed:33608508)
Specific Function
Zinc ion transmembrane transporter activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
10-30 138-158 169-189 214-234 381-401 417-436
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0052350|Zinc transporter SLC39A7 (SLC39A7)
ATGGCCAGAGGCCTGGGGGCCCCCCACTGGGTGGCCGTGGGACTGCTGACCTGGGCGACC
TTGGGGCTTCTGGTGGCTGGACTCGGGGGTCATGACGACCTGCACGACGATCTGCAAGAG
GACTTCCATGGCCACAGCCACAGGCACTCACATGAAGATTTCCACCATGGCCACAGCCAT
GCCCATGGCCATGGCCACACTCACGAGAGCATCTGGCATGGACATACCCACGATCACGAC
CATGGACATTCACATGAGGATTTACACCATGGCCATAGCCATGGCTACTCCCATGAGAGC
CTCTACCACAGAGGACATGGACATGACCATGAGCATAGCCATGGAGGCTATGGGGAGTCT
GGGGCTCCAGGCATCAAGCAGGACCTGGATGCTGTCACTCTCTGGGCTTATGCACTGGGG
GCCACAGTGCTGATCTCAGCAGCTCCATTTTTTGTCCTCTTCCTTATCCCCGTGGAGTCG
AACTCTCCCCGGCATCGCTCTCTACTTCAGATCTTGCTCAGTTTTGCTTCCGGTGGGCTC
CTGGGAGATGCTTTCCTGCACCTCATTCCTCATGCTCTTGAACCTCATTCTCACCACACT
CTGGAGCAACCCGGACATGGACACTCCCACAGTGGCCAGGGCCCCATTCTGTCTGTGGGA
CTGTGGGTTCTCAGTGGAATTGTTGCCTTTCTTGTCGTGGAGAAATTTGTGAGACATGTG
AAAGGAGGACATGGTCACAGTCATGGACATGGACACGCTCACAGTCATACACGTGGAAGT
CATGGACATGGAAGACAAGAGCGTTCTACCAAGGAGAAGCAGAGCTCAGAGGAAGAAGAA
AAGGAAACAAGAGGGGTTCAGAAGAGGCGAGGAGGGAGCACAGTACCCAAAGATGGGCCA
GTGAGACCTCAGAACGCTGAAGAAGAAAAAAGAGGCTTAGACCTGCGTGTGTCGGGGTAC
CTGAATCTGGCTGCTGACTTGGCACACAACTTCACTGATGGTCTGGCCATTGGGGCTTCC
TTTCGAGGGGGCCGGGGACTAGGGATCCTGACCACAATGACTGTCCTGCTACATGAAGTG
CCCCACGAGGTCGGAGACTTTGCCATCTTGGTCCAGTCTGGCTGCAGCAAAAAGCAGGCG
ATGCGTCTGCAACTACTGACAGCAGTAGGGGCACTGGCAGGCACAGCCTGTGCCCTTCTC
ACTGAAGGAGGAGCAGTGGGCAGTGAAATTGCAGGTGGTGCAGGTCCTGGCTGGGTCCTG
CCATTTACTGCAGGTGGCTTTATCTACGTAGCAACAGTGTCTGTGTTGCCCGAGCTGCTG
AGGGAGGCATCACCATTGCAATCACTTCTGGAGGTGCTGGGGCTGCTGGGGGGAGTTATC
ATGATGGTGCTGATTGCCCACCTTGAGTGA
Chromosome Location
6
Locus
6p21.32
External Identifiers
ResourceLink
UniProtKB IDQ92504
UniProtKB Entry NameS39A7_HUMAN
GeneCard IDSLC39A7
HGNC IDHGNC:4927
PDB ID(s)8GZE
KEGG IDhsa:7922
NCBI Gene ID7922
General References
  1. Ando A, Kikuti YY, Shigenari A, Kawata H, Okamoto N, Shiina T, Chen L, Ikemura T, Abe K, Kimura M, Inoko H: cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. Genomics. 1996 Aug 1;35(3):600-2. [Article]
  2. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Taylor KM, Morgan HE, Johnson A, Nicholson RI: Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters. Biochem J. 2004 Jan 1;377(Pt 1):131-9. doi: 10.1042/BJ20031183. [Article]
  5. Huang L, Kirschke CP, Zhang Y, Yu YY: The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. J Biol Chem. 2005 Apr 15;280(15):15456-63. doi: 10.1074/jbc.M412188200. Epub 2005 Feb 10. [Article]
  6. Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schutz C, Walter U, Gambaryan S, Sickmann A: Phosphoproteome of resting human platelets. J Proteome Res. 2008 Feb;7(2):526-34. Epub 2007 Dec 19. [Article]
  7. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. [Article]
  8. Taylor KM, Hiscox S, Nicholson RI, Hogstrand C, Kille P: Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7. Sci Signal. 2012 Feb 7;5(210):ra11. doi: 10.1126/scisignal.2002585. [Article]
  9. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  10. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Zinc chlorideapproved, investigationalunknowntransportersubstrateDetails
Zinc sulfate, unspecified formapproved, experimentalunknowntransportersubstrateDetails