Zinc transporter ZIP4

BE0009894ProteinHumansSLC39A4

Selective transporter that mediates the uptake of Zn(2+) (PubMed:17202136, PubMed:22242765, PubMed:27321477, PubMed:28875161, PubMed:31164399, PubMed:31914589, PubMed:31979155, PubMed:33837739, PubMed:36473915). It is acted on by 2 drugs in DrugBank.

Gene name
SLC39A4
UniProtKB entry
Q6P5W5Swiss-Prot
Cellular location
Cell membrane
Residues / weight
647 residues · 68,407 Da
Also known as
Solute carrier family 39 member 4 · ZIP-4 · ZIP4 · Zrt- and Irt-like protein 4

Resolves to

Protein
UniProtQ6P5W5UniProt nameS39A4_HUMAN
Gene
HGNCHGNC:17129NCBI Gene55630GeneCardsSLC39A4
Pharmacology
KEGGhsa:55630
Drugs

What you can answer from here — as of April 13, 2020

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Zinc transporter ZIP4, how selective are they, and which programs against it are still in active trials?

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