Zinc transporter ZIP4

Details

Name
Zinc transporter ZIP4
Kind
protein
Synonyms
  • Solute carrier family 39 member 4
  • ZIP-4
  • ZIP4
  • Zrt- and Irt-like protein 4
Gene Name
SLC39A4
UniProtKB Entry
Q6P5W5Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0052351|Zinc transporter ZIP4
MASLVSLELGLLLAVLVVTATASPPAGLLSLLTSGQGALDQEALGGLLNTLADRVHCANG
PCGKCLSVEDALGLGEPEGSGLPPGPVLEARYVARLSAAAVLYLSNPEGTCEDARAGLWA
SHADHLLALLESPKALTPGLSWLLQRMQARAAGQTPKMACVDIPQLLEEAVGAGAPGSAG
GVLAALLDHVRSGSCFHALPSPQYFVDFVFQQHSSEVPMTLAELSALMQRLGVGREAHSD
HSHRHRGASSRDPVPLISSSNSSSVWDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPAL
LQQQLSGACTSQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLLLLTCTGCRGVTHYI
LQTFLSLAVGAVTGDAVLHLTPKVLGLHTHSEEGLSPQPTWRLLAMLAGLYAFFLFENLF
NLLLPRDPEDLEDGPCGHSSHSHGGHSHGVSLQLAPSELRQPKPPHEGSRADLVAEESPE
LLNPEPRRLSPELRLLPYMITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPH
ELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALAVGVSEESEAWILAVATGLFLYV
ALCDMLPAMLKVRDPRPWLLFLLHNVGLLGGWTVLLLLSLYEDDITF
Number of residues
647
Molecular Weight
68406.75
Theoretical pI
Not Available
GO Classification
Functions
identical protein binding / metal ion binding / monoatomic cation / zinc ion binding / zinc ion sensor activity / zinc ion sequestering activity
Processes
intracellular monoatomic cation homeostasis / intracellular zinc ion homeostasis / zinc ion transmembrane transport
General Function
Selective transporter that mediates the uptake of Zn(2+) (PubMed:17202136, PubMed:22242765, PubMed:27321477, PubMed:28875161, PubMed:31164399, PubMed:31914589, PubMed:31979155, PubMed:33837739, PubMed:36473915). Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability (PubMed:17202136, PubMed:32348750). Exhibits also polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:22242765, PubMed:31914589)
Specific Function
Identical protein binding
Pfam Domain Function
Signal Regions
1-22
Transmembrane Regions
328-348 360-380 403-423 499-518 527-553 559-579 587-607 618-638
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052352|Zinc transporter ZIP4 (SLC39A4)
ATGGCGTCCCTGGTCTCGCTGGAGCTGGGGCTGCTTCTGGCTGTGCTGGTGGTGACGGCG
ACGGCGTCCCCGCCTGCTGGTCTGCTGAGCCTGCTCACCTCTGGCCAGGGCGCTCTGGAT
CAAGAGGCTCTGGGCGGCCTGTTAAATACGCTGGCGGACCGTGTGCACTGCGCCAACGGG
CCGTGTGGAAAGTGCCTGTCTGTGGAGGACGCCCTGGGCCTGGGCGAGCCTGAGGGGTCA
GGGCTGCCCCCGGGCCCGGTCCTGGAGGCCAGGTACGTCGCCCGCCTCAGTGCCGCCGCC
GTCCTGTACCTCAGCAACCCCGAGGGCACCTGTGAGGACGCTCGGGCTGGCCTCTGGGCC
TCTCATGCAGACCACCTCCTGGCCCTGCTCGAGAGCCCCAAGGCCCTGACCCCGGGCCTG
AGCTGGCTGCTGCAGAGGATGCAGGCCCGGGCTGCCGGCCAGACCCCCAAGATGGCCTGC
GTAGATATCCCTCAGCTGCTGGAGGAGGCGGTGGGGGCGGGGGCTCCGGGCAGTGCTGGC
GGCGTCCTGGCTGCCCTGCTGGACCATGTCAGGAGCGGGTCTTGCTTCCACGCCTTGCCG
AGCCCTCAGTACTTCGTGGACTTTGTGTTCCAGCAGCACAGCAGCGAGGTCCCTATGACG
CTGGCCGAGCTGTCAGCCTTGATGCAGCGCCTGGGGGTGGGCAGGGAGGCCCACAGTGAC
CACAGTCATCGGCACAGGGGAGCCAGCAGCCGGGACCCTGTGCCCCTCATCAGCTCCAGC
AACAGCTCCAGTGTGTGGGACACGGTATGCCTGAGTGCCAGGGACGTGATGGCTGCATAT
GGACTGTCGGAACAGGCTGGGGTGACCCCGGAGGCCTGGGCCCAACTGAGCCCTGCCCTG
CTCCAACAGCAGCTGAGTGGAGCCTGCACCTCCCAGTCCAGGCCCCCCGTCCAGGACCAG
CTCAGCCAGTCAGAGAGGTATCTGTACGGCTCCCTGGCCACGCTGCTCATCTGCCTCTGC
GCGGTCTTTGGCCTCCTGCTGCTGACCTGCACTGGCTGCAGGGGGGTCACCCACTACATC
CTGCAGACCTTCCTGAGCCTGGCAGTGGGTGCAGTCACTGGGGACGCTGTCCTGCATCTG
ACGCCCAAGGTGCTGGGGCTGCATACACACAGCGAAGAGGGCCTCAGCCCACAGCCCACC
TGGCGCCTCCTGGCTATGCTGGCCGGGCTCTACGCCTTCTTCCTGTTTGAGAACCTCTTC
AATCTCCTGCTGCCCAGGGACCCGGAGGACCTGGAGGACGGGCCCTGCGGCCACAGCAGC
CATAGCCACGGGGGCCACAGCCACGGTGTGTCCCTGCAGCTGGCACCCAGCGAGCTCCGG
CAGCCCAAGCCCCCCCACGAGGGCTCCCGCGCAGACCTGGTGGCGGAGGAGAGCCCGGAG
CTGCTGAACCCTGAGCCCAGGAGACTGAGCCCAGAGTTGAGGCTACTGCCCTATATGATC
ACTCTGGGCGACGCCGTGCACAACTTCGCCGACGGGCTGGCCGTGGGCGCCGCCTTCGCG
TCCTCCTGGAAGACCGGGCTGGCCACCTCGCTGGCCGTGTTCTGCCACGAGTTGCCACAC
GAGCTGGGGGACTTCGCCGCCTTGCTGCACGCGGGGCTGTCCGTGCGCCAAGCACTGCTG
CTGAACCTGGCCTCCGCGCTCACGGCCTTCGCTGGTCTCTACGTGGCACTCGCGGTTGGA
GTCAGCGAGGAGAGCGAGGCCTGGATCCTGGCAGTGGCCACCGGCCTGTTCCTCTACGTA
GCACTCTGCGACATGCTCCCGGCGATGTTGAAAGTACGGGACCCGCGGCCCTGGCTCCTC
TTCCTGCTGCACAACGTGGGCCTGCTGGGCGGCTGGACCGTCCTGCTGCTGCTGTCCCTG
TACGAGGATGACATCACCTTCTGA
Chromosome Location
8
Locus
8q24.3
External Identifiers
ResourceLink
UniProtKB IDQ6P5W5
UniProtKB Entry NameS39A4_HUMAN
GeneCard IDSLC39A4
HGNC IDHGNC:17129
KEGG IDhsa:55630
NCBI Gene ID55630
General References
  1. Kury S, Dreno B, Bezieau S, Giraudet S, Kharfi M, Kamoun R, Moisan JP: Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. Nat Genet. 2002 Jul;31(3):239-40. doi: 10.1038/ng913. Epub 2002 Jun 17. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L 3rd, Engels R, Glockner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES: DNA sequence and analysis of human chromosome 8. Nature. 2006 Jan 19;439(7074):331-5. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Wang K, Zhou B, Kuo YM, Zemansky J, Gitschier J: A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am J Hum Genet. 2002 Jul;71(1):66-73. doi: 10.1086/341125. Epub 2002 May 24. [Article]
  6. Kim BE, Wang F, Dufner-Beattie J, Andrews GK, Eide DJ, Petris MJ: Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. J Biol Chem. 2004 Feb 6;279(6):4523-30. doi: 10.1074/jbc.M310799200. Epub 2003 Nov 11. [Article]
  7. Nakano A, Nakano H, Nomura K, Toyomaki Y, Hanada K: Novel SLC39A4 mutations in acrodermatitis enteropathica. J Invest Dermatol. 2003 Jun;120(6):963-6. doi: 10.1046/j.1523-1747.2003.12243.x. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Zinc chlorideapproved, investigationalunknowntransportersubstrateDetails
Zinc sulfate, unspecified formapproved, experimentalunknowntransportersubstrateDetails