Probable proton-coupled zinc antiporter SLC30A3

BE0009895ProteinHumansSLC30A3

Probable proton-coupled zinc ion antiporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain. It is acted on by 2 drugs in DrugBank.

Gene name
SLC30A3
UniProtKB entry
Q99726Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Residues / weight
388 residues · 41,945 Da
Also known as
Solute carrier family 30 member 3 · Zinc transporter 3 · ZnT-3 · ZNT3

Resolves to

Protein
UniProtQ99726UniProt nameZNT3_HUMAN
Gene
HGNCHGNC:11014NCBI Gene7781GeneCardsSLC30A3
Pharmacology
KEGGhsa:7781
Structure
PDB8XN1PDB9JJ1PDB9JJ2
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Probable proton-coupled zinc antiporter SLC30A3, how selective are they, and which programs against it are still in active trials?

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