Proton-coupled zinc antiporter SLC30A8

BE0009896ProteinHumansSLC30A8

Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion. It is acted on by 2 drugs in DrugBank.

Gene name
SLC30A8
UniProtKB entry
Q8IWU4Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle membrane
Residues / weight
369 residues · 40,754 Da
Also known as
Solute carrier family 30 member 8 · Zinc transporter 8 · ZnT-8 · ZNT8

Resolves to

Protein
UniProtQ8IWU4UniProt nameZNT8_HUMAN
Gene
HGNCHGNC:20303NCBI Gene169026GeneCardsSLC30A8
Pharmacology
KEGGhsa:169026
Structure
PDB6XPDPDB6XPEPDB6XPF
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proton-coupled zinc antiporter SLC30A8, how selective are they, and which programs against it are still in active trials?

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