Zinc transporter ZIP12

Details

Name
Zinc transporter ZIP12
Kind
protein
Synonyms
  • LIV-1 subfamily of ZIP zinc transporter 8
  • LZT-Hs8
  • Solute carrier family 39 member 12
  • ZIP-12
  • ZIP12
  • Zrt- and Irt-like protein 12
Gene Name
SLC39A12
UniProtKB Entry
Q504Y0Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0052357|Zinc transporter ZIP12
MCFRTKLSVSWVPLFLLLSRVFSTETDKPSAQDSRSRGSSGQPADLLQVLSAGDHPPHNH
SRSLIKTLLEKTGCPRRRNGMQGDCNLCFEPDALLLIAGGNFEDQLREEVVQRVSLLLLY
YIIHQEEICSSKLNMSNKEYKFYLHSLLSLRQDEDSSFLSQNETEDILAFTRQYFDTSQS
QCMETKTLQKKSGIVSSEGANESTLPQLAAMIITLSLQGVCLGQGNLPSPDYFTEYIFSS
LNRTNTLRLSELDQLLNTLWTRSTCIKNEKIHQFQRKQNNIITHDQDYSNFSSSMEKESE
DGPVSWDQTCFSARQLVEIFLQKGLSLISKEDFKQMSPGIIQQLLSCSCHLPKDQQAKLP
PTTLEKYGYSTVAVTLLTLGSMLGTALVLFHSCEENYRLILQLFVGLAVGTLSGDALLHL
IPQVLGLHKQEAPEFGHFHESKGHIWKLMGLIGGIHGFFLIEKCFILLVSPNDKQGLSLV
NGHVGHSHHLALNSELSDQAGRGKSASTIQLKSPEDSQAAEMPIGSMTASNRKCKAISLL
AIMILVGDSLHNFADGLAIGAAFSSSSESGVTTTIAILCHEIPHEMGDFAVLLSSGLSMK
TAILMNFISSLTAFMGLYIGLSVSADPCVQDWIFTVTAGMFLYLSLVEMLPEMTHVQTQR
PWMMFLLQNFGLILGWLSLLLLAIYEQNIKI
Number of residues
691
Molecular Weight
76665.43
Theoretical pI
Not Available
GO Classification
Functions
monoatomic cation
Processes
intracellular monoatomic cation homeostasis / neural tube formation / neuron projection extension / positive regulation of sprouting angiogenesis / response to decreased oxygen levels
Components
plasma membrane
General Function
Uniporter that promotes Zn(2+) import from the extracellular space to the cytoplasm across the cell membrane. The transport activity is temperature dependent. May play a role in neurulation and neurite extension. May play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis
Specific Function
Monoatomic cation
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
203-223 370-390 399-419 449-469 539-559 603-623 632-652 664-684
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0052358|Zinc transporter ZIP12 (SLC39A12)
ATGTGCTTCCGGACAAAGCTCTCAGTATCCTGGGTGCCATTGTTTCTTCTACTCAGCCGT
GTTTTTTCTACTGAGACAGACAAACCCTCAGCCCAGGATAGCAGAAGCCGTGGGAGTTCA
GGCCAACCGGCAGACCTGCTACAGGTTCTCTCTGCTGGTGACCACCCACCCCACAACCAC
TCAAGAAGCCTCATCAAAACATTGTTGGAGAAAACTGGGTGCCCACGGAGGAGAAACGGA
ATGCAAGGAGATTGCAATCTGTGCTTTGAACCAGATGCACTATTACTAATAGCTGGAGGA
AATTTTGAAGATCAGCTTAGAGAAGAAGTGGTCCAGAGAGTTTCTCTTCTCCTTCTCTAT
TACATTATTCATCAGGAAGAGATCTGTTCTTCAAAGCTCAACATGAGTAATAAAGAGTAT
AAATTTTACCTACACAGCCTACTGAGCCTCAGGCAGGATGAAGATTCCTCTTTCCTTTCA
CAGAATGAGACAGAAGATATCTTGGCTTTCACCAGGCAGTACTTTGACACTTCTCAAAGC
CAGTGTATGGAAACCAAAACGCTGCAGAAAAAATCTGGAATAGTGAGCAGTGAAGGTGCT
AATGAAAGTACGCTTCCTCAGTTGGCAGCCATGATCATTACTTTGTCCCTCCAGGGTGTT
TGTCTGGGACAAGGAAACTTGCCTTCCCCAGACTACTTTACAGAATATATTTTCAGTTCC
TTGAATCGTACGAATACCCTCCGCCTATCAGAACTAGACCAACTCCTCAACACTCTCTGG
ACCAGAAGTACTTGTATCAAAAATGAGAAAATCCATCAATTTCAAAGGAAACAAAACAAC
ATAATAACCCATGATCAGGACTATTCTAATTTCTCTTCATCCATGGAAAAAGAGTCTGAG
GATGGTCCAGTTTCCTGGGATCAGACCTGCTTCTCTGCTAGGCAGCTGGTGGAGATATTT
CTACAGAAGGGCCTCTCACTCATTTCTAAGGAGGACTTTAAGCAAATGAGTCCAGGGATC
ATCCAGCAGCTCCTCAGCTGCTCCTGCCACTTACCCAAGGACCAACAAGCAAAGCTGCCA
CCTACCACTCTGGAGAAATACGGCTACAGCACGGTGGCTGTCACCCTTCTCACACTGGGC
TCCATGCTGGGGACAGCGCTGGTCCTTTTCCATAGCTGTGAGGAGAACTACAGGCTTATC
TTACAGCTGTTTGTGGGCTTGGCCGTCGGGACACTGTCTGGGGACGCTCTGCTCCACCTT
ATCCCTCAGGTTCTTGGTTTACATAAGCAGGAAGCCCCAGAATTTGGGCATTTCCATGAA
AGCAAAGGTCATATTTGGAAACTGATGGGATTAATTGGAGGCATCCATGGATTTTTCTTG
ATAGAAAAATGTTTTATTCTTCTTGTATCACCAAATGACAAGCAGGGCCTGTCATTGGTT
AATGGGCACGTGGGTCATTCCCACCATCTTGCACTCAACTCTGAATTAAGTGACCAGGCA
GGCAGAGGCAAATCTGCTTCAACTATCCAGTTGAAAAGCCCAGAAGATTCACAGGCAGCT
GAAATGCCTATAGGCAGTATGACAGCCTCCAACAGAAAATGTAAAGCCATTAGCTTGTTA
GCAATCATGATTCTGGTTGGGGACAGCCTGCATAATTTTGCAGATGGCCTAGCCATAGGA
GCAGCCTTCTCATCATCATCCGAGTCAGGAGTGACCACTACGATTGCTATCTTGTGTCAT
GAAATCCCACATGAAATGGGAGACTTTGCCGTGCTCTTAAGCTCTGGACTTTCTATGAAG
ACTGCCATCCTGATGAATTTTATAAGCTCCCTAACTGCCTTCATGGGATTATACATTGGC
CTTTCCGTGTCAGCTGATCCATGTGTTCAAGACTGGATCTTCACAGTCACTGCTGGGATG
TTCTTATATTTATCCTTGGTTGAAATGCTTCCTGAAATGACTCATGTTCAAACACAACGA
CCCTGGATGATGTTTCTCCTGCAAAACTTTGGATTGATCCTAGGTTGGCTTTCTCTCCTG
CTCTTGGCTATATATGAGCAAAATATTAAAATATAA
Chromosome Location
10
Locus
10p12.33
External Identifiers
ResourceLink
UniProtKB IDQ504Y0
UniProtKB Entry NameS39AC_HUMAN
GeneCard IDSLC39A12
HGNC IDHGNC:20860
KEGG IDhsa:221074
NCBI Gene ID221074
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  2. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K: Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. Mol Vis. 2002 Jun 15;8:205-20. [Article]
  5. Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S: Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Genome Res. 2004 Sep;14(9):1711-8. doi: 10.1101/gr.2435604. [Article]
  6. Bly M: Examination of the zinc transporter gene, SLC39A12. Schizophr Res. 2006 Jan 31;81(2-3):321-2. doi: 10.1016/j.schres.2005.07.039. Epub 2005 Nov 28. [Article]
  7. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Zinc chlorideapproved, investigationalunknowntransportersubstrateDetails
Zinc sulfate, unspecified formapproved, experimentalunknowntransportersubstrateDetails