Proton-coupled zinc antiporter SLC30A5

BE0009898ProteinHumansSLC30A5

Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:11904301, PubMed:15525635, PubMed:15994300, PubMed:19366695, PubMed:22529353). It is acted on by 2 drugs in DrugBank.

Gene name
SLC30A5
UniProtKB entry
Q8TAD4Swiss-Prot
Cellular location
Golgi apparatus, Golgi stack membrane
Residues / weight
765 residues · 84,046 Da
Also known as
hZTL1 · Solute carrier family 30 member 5 · Zinc transporter 5 · ZnT-5 · ZnT-like transporter 1

Resolves to

Protein
UniProtQ8TAD4UniProt nameZNT5_HUMAN
Gene
HGNCHGNC:19089NCBI Gene64924GeneCardsSLC30A5
Pharmacology
KEGGhsa:64924
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proton-coupled zinc antiporter SLC30A5, how selective are they, and which programs against it are still in active trials?

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