Metal cation symporter ZIP8

BE0009901ProteinHumansSLC39A8

Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity (PubMed:12504855, PubMed:22898811, PubMed:23403290, PubMed:26637978, PubMed:29337306, PubMed:29453449). It is acted on by 4 drugs in DrugBank.

Gene name
SLC39A8
UniProtKB entry
Q9C0K1Swiss-Prot
Cellular location
Cell membrane
Residues / weight
460 residues · 49,630 Da
Also known as
BCG-induced integral membrane protein in monocyte clone 103 protein · BIGM103 · LIV-1 subfamily of ZIP zinc transporter 6 · LZT-Hs6 · Solute carrier family 39 member 8

Resolves to

Protein
UniProtQ9C0K1UniProt nameS39A8_HUMAN
Gene
HGNCHGNC:20862NCBI Gene64116GeneCardsSLC39A8
Pharmacology
KEGGhsa:64116
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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26GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Metal cation symporter ZIP8, how selective are they, and which programs against it are still in active trials?

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