Zinc transporter ZIP11

Details

Name
Zinc transporter ZIP11
Kind
protein
Synonyms
  • C17orf26
  • Solute carrier family 39 member 11
  • ZIP-11
  • ZIP11
  • Zrt- and Irt-like protein 11
Gene Name
SLC39A11
UniProtKB Entry
Q8N1S5Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0052375|Zinc transporter ZIP11
MLQGHSSVFQALLGTFFTWGMTAAGAALVFVFSSGQRRILDGSLGFAAGVMLAASYWSLL
APAVEMATSSGGFGAFAFFPVAVGFTLGAAFVYLADLLMPHLGAAEDPQTTLALNFGSTL
MKKKSDPEGPALLFPESELSIRIGRAGLLSDKSENGEAYQRKKAAATGLPEGPAVPVPSR
GNLAQPGGSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTASATFESARNLAIGIGIQ
NFPEGLAVSLPLRGAGFSTWRAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYALAFAAG
AMVYVVMDDIIPEAQISGNGKLASWASILGFVVMMSLDVGLG
Number of residues
342
Molecular Weight
35395.665
Theoretical pI
Not Available
GO Classification
Functions
copper ion transmembrane transporter activity
Processes
zinc ion import across plasma membrane
General Function
Zinc importer that regulates cytosolic zinc concentrations either via zinc influx from the extracellular compartment or efflux from intracellular organelles such as Golgi apparatus. May transport copper ions as well. The transport mechanism remains to be elucidated
Specific Function
Copper ion transmembrane transporter activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
12-32 44-64 72-92 194-214 263-285 290-307 322-342
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052376|Zinc transporter ZIP11 (SLC39A11)
ATGCTCCAAGGCCACAGCTCTGTGTTCCAGGCCTTGCTGGGGACCTTCTTCACCTGGGGG
ATGACAGCAGCTGGGGCAGCTCTCGTGTTCGTATTCTCTAGTGGACAGAGGCGGATCTTA
GATGGAAGTCTTGGCTTTGCTGCAGGGGTCATGTTGGCAGCTTCCTATTGGTCTCTTCTG
GCCCCAGCAGTTGAGATGGCCACGTCCTCTGGGGGCTTCGGTGCCTTTGCCTTCTTCCCT
GTGGCTGTTGGCTTCACCCTTGGAGCGGCTTTTGTCTACTTGGCTGACCTCCTGATGCCT
CACTTGGGTGCAGCAGAAGACCCCCAGACGACCCTGGCACTGAACTTCGGCTCTACGTTG
ATGAAGAAGAAGTCTGATCCTGAGGGTCCCGCGCTGCTCTTCCCTGAGAGTGAACTTTCC
ATCCGGATAGGTAGAGCTGGGCTTCTTTCAGACAAGAGTGAGAATGGTGAGGCATATCAG
AGAAAGAAGGCGGCAGCCACTGGCCTTCCAGAGGGTCCTGCTGTCCCTGTGCCTTCTCGA
GGGAATCTGGCACAGCCCGGCGGCAGCAGCTGGAGGAGGATCGCACTGCTCATCTTGGCC
ATCACTATACACAACGTTCCAGAGGGTCTCGCTGTTGGAGTTGGATTTGGGGCTATAGAA
AAGACGGCATCTGCTACCTTTGAGAGTGCCAGGAATTTGGCCATTGGAATCGGGATCCAG
AATTTCCCCGAGGGCCTGGCTGTCAGCCTTCCCTTGCGAGGGGCAGGCTTCTCCACCTGG
AGAGCTTTCTGGTATGGGCAGCTGAGCGGCATGGTGGAGCCCCTGGCCGGGGTCTTTGGT
GCCTTTGCCGTGGTGCTGGCTGAGCCCATCCTGCCCTACGCTCTGGCCTTTGCTGCCGGT
GCCATGGTCTACGTGGTCATGGACGACATCATCCCCGAAGCCCAGATCAGTGGTAATGGG
AAACTGGCATCCTGGGCCTCCATCCTGGGATTTGTAGTGATGATGTCACTGGACGTTGGC
CTGGGCTAG
Chromosome Location
17
Locus
17q24.3-q25.1
External Identifiers
ResourceLink
UniProtKB IDQ8N1S5
UniProtKB Entry NameS39AB_HUMAN
GeneCard IDSLC39A11
HGNC IDHGNC:14463
KEGG IDhsa:201266
NCBI Gene ID201266
General References
  1. Bagheri-Fam S, Ferraz C, Demaille J, Scherer G, Pfeifer D: Comparative genomics of the SOX9 region in human and Fugu rubripes: conservation of short regulatory sequence elements within large intergenic regions. Genomics. 2001 Nov;78(1-2):73-82. doi: 10.1006/geno.2001.6648. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature. 2006 Apr 20;440(7087):1045-9. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Zinc chlorideapproved, investigationalunknowntransportersubstrateDetails
Zinc sulfate, unspecified formapproved, experimentalunknowntransportersubstrateDetails