Zinc transporter 6

BE0009907ProteinHumansSLC30A6

Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15994300, PubMed:19366695, PubMed:19759014). It is acted on by 2 drugs in DrugBank.

Gene name
SLC30A6
UniProtKB entry
Q6NXT4Swiss-Prot
Cellular location
Golgi apparatus, trans-Golgi network membrane
Residues / weight
461 residues · 51,115 Da
Also known as
Solute carrier family 30 member 6 · ZnT-6 · ZNT6

Resolves to

Protein
UniProtQ6NXT4UniProt nameZNT6_HUMAN
Gene
HGNCHGNC:19305NCBI Gene55676GeneCardsSLC30A6
Pharmacology
KEGGhsa:55676
Drugs

What you can answer from here — as of April 13, 2020

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Zinc transporter 6, how selective are they, and which programs against it are still in active trials?

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