Histidine-rich glycoprotein

BE0009910ProteinHumansHRG

Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. It is acted on by 3 drugs in DrugBank.

Gene name
HRG
UniProtKB entry
P04196Swiss-Prot
Cellular location
Secreted
Residues / weight
525 residues · 59,578 Da
Also known as
Histidine-proline-rich glycoprotein · HPRG

Resolves to

Protein
UniProtP04196UniProt nameHRG_HUMAN
Gene
HGNCHGNC:5181NCBI Gene3273GeneCardsHRG
Pharmacology
KEGGhsa:3273
Drugs

What you can answer from here — as of April 15, 2020

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histidine-rich glycoprotein, how selective are they, and which programs against it are still in active trials?

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