C->U-editing enzyme APOBEC-1

BE0009915ProteinHumansAPOBEC1

Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs (PubMed:30844405). It is acted on by 2 drugs in DrugBank.

Gene name
APOBEC1
UniProtKB entry
P41238Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
236 residues · 28,191 Da
Also known as
3.5.4.- · APO1 · APOBEC-1 · Apolipoprotein B mRNA-editing enzyme 1 · Apolipoprotein B mRNA-editing enzyme catalytic subunit 1

Resolves to

Protein
UniProtP41238UniProt nameABEC1_HUMAN
Gene
HGNCHGNC:604NCBI Gene339GeneCardsAPOBEC1
Pharmacology
KEGGhsa:339
Structure
PDB6X91
Drugs

What you can answer from here — as of April 16, 2020

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on C->U-editing enzyme APOBEC-1, how selective are they, and which programs against it are still in active trials?

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