Transmembrane protease serine 2

BE0009920ProteinHumansTMPRSS2

Plasma membrane-anchored serine protease that cleaves at arginine residues (PubMed:32703818, PubMed:35676539, PubMed:37990007, PubMed:38964328). It is acted on by 5 drugs in DrugBank.

Gene name
TMPRSS2
UniProtKB entry
O15393Swiss-Prot
Cellular location
Cell membrane
Residues / weight
492 residues · 53,859 Da
Also known as
3.4.21.122 · PRSS10 · Serine protease 10

Resolves to

Protein
UniProtO15393UniProt nameTMPS2_HUMAN
Gene
HGNCHGNC:11876NCBI Gene7113GeneCardsTMPRSS2
Pharmacology
IUPHAR/GtoPdb2421KEGGhsa:7113
Structure
PDB7MEQPDB7XYDPDB7Y0E
Drugs

What you can answer from here — as of April 30, 2020

5DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transmembrane protease serine 2, how selective are they, and which programs against it are still in active trials?

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