Metallo-beta-lactamase type 2

BE0009973ProteinKlebsiella pneumoniaeblaNDM-1

Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. It is acted on by 4 drugs in DrugBank.

Gene name
blaNDM-1
UniProtKB entry
C7C422Swiss-Prot
Cellular location
Periplasm
Residues / weight
270 residues · 28,499 Da
Also known as
3.5.2.6 · B2 metallo-beta-lactamase · Beta-lactamase type II · Metallo-beta-lactamase NDM-1 · Metallo-beta-lactamase type II

Resolves to

Protein
UniProtC7C422UniProt nameBLAN1_KLEPN
Gene
NCBI Gene11934636
Pharmacology
KEGGag:CAZ39946
Structure
PDB3PG4PDB3RKJPDB3RKK
Drugs

What you can answer from here — as of May 15, 2020

4DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Metallo-beta-lactamase type 2, how selective are they, and which programs against it are still in active trials?

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