Dihydrofolate reductase

BE0009974ProteinGallus gallusDHFR

Key enzyme in folate metabolism. It is acted on by 1 drug in DrugBank.

Gene name
DHFR
UniProtKB entry
P00378Swiss-Prot
Residues / weight
189 residues · 21,650 Da
Also known as
1.5.1.3

Resolves to

Protein
UniProtP00378UniProt nameDYR_CHICK
Structure
PDB1DR1PDB1DR2PDB1DR3
Drugs

What you can answer from here — as of May 16, 2020

1DrugApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dihydrofolate reductase, how selective are they, and which programs against it are still in active trials?

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