Urea

DB03904ApprovedInvestigationalSmall moleculeDiuretics, OsmoticKeratolytic Agents

Urea is a keratolytic emollient used to treat hyperkeratotic lesions and moisturize the skin. A compound formed in the liver from ammonia produced by the deamination of amino acids.

Chemical structure of Urea
Mechanism
Curator reviewed
Primary indication
Urea is used topically for debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar.Curator reviewed · 22 structured indications
Formula / weight
CH4N2O · 60.0553 g/mol (avg)
First approval
Canada, 1997 · United States, 2017
Also known as
Carbamide · Carbonyldiamide
Code names
E-927A · INS-927A · INS NO.927A · NSC-34375
Brand names
  • Cem-urea
  • Umecta
  • Utopic

Resolves to

Compound
UNII8W8T17847WCAS57-13-6ChEMBLCHEMBL985ChEBI48376PubChem1176KEGGD00023
Clinical / RWD
RxNorm11002ATCB05BC02ATCD02AE01ATCD02AE51PharmGKBPA451831
Structure
InChIKeyXSQUKJJJFZCRTK-UHFFFAOYSA-NSMILESNC(N)=O
Targets
P00378DHFRP05089ARG1P00918CA2P35222CTNNB1Q8XB74msrP
Transporters
Q15849SLC14A2Q13336SLC14A1

What you can answer from here — as of September 28, 2026

5Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
2TransportersSubstrate / inhibitor direction, not just membership
Listed above
72Clinical trialsPhase, status and sponsor resolved per trial
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22Structured indicationsCondition, population, route and combination as fields, not prose
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346Marketed productsAcross 10 countries and 124 labellers
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3ATC codesIncluding every combination product, plus 10 drug categories
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11+ReferencesStructured and connected to the statements they support
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