NADPH oxidase 2

BE0009985ProteinHumansCYBB

Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:15338276, PubMed:36241643, PubMed:36413210, PubMed:38355798). It is acted on by 2 drugs in DrugBank.

Gene name
CYBB
UniProtKB entry
P04839Swiss-Prot
Cellular location
Cell membrane
Residues / weight
570 residues · 65,335 Da
Also known as
1.6.3.- · CGD91-phox · Cytochrome b-245 heavy chain · Cytochrome b(558) subunit beta · Cytochrome b558 subunit beta

Resolves to

Protein
UniProtP04839UniProt nameCY24B_HUMAN
Gene
HGNCHGNC:2578NCBI Gene1536GeneCardsCYBB
Pharmacology
IUPHAR/GtoPdb3002KEGGhsa:1536
Structure
PDB3A1FPDB7U8GPDB8GZ3
Drugs

What you can answer from here — as of February 11, 2025

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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13GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which compounds in development act on NADPH oxidase 2, and which indications are they being tested in?

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