Diphenyleneiodonium

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Diphenyleneiodonium
DrugBank Accession Number
DB17025
Background

An NADPH oxidase 2 (NOX2) inhibitor.1

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 279.1
Monoisotopic: 278.96652
Chemical Formula
C12H8I
Synonyms
  • Dibenziodolium

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Diphenyleneiodonium chloride7M9D81YZ2N3895-92-9Not applicable

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
6HJ411TU98
CAS number
244-54-2
InChI Key
QFXKXRXFBRLLPQ-UHFFFAOYSA-N
InChI
InChI=1S/C12H8I/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11/h1-8H/q+1
IUPAC Name
8lambda3-iodatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-8-ylium
SMILES
[I+]1C2=CC=CC=C2C2=C1C=CC=C2

References

General References
  1. Zhu Y, Chen X, Lu Y, Fan S, Yang Y, Chen Q, Huang Q, Xia L, Wei Y, Zheng J, Liu X: Diphenyleneiodonium enhances P2X7 dependent non-opsonized phagocytosis and suppresses inflammasome activation via blocking CX43-mediated ATP leakage. Pharmacol Res. 2021 Apr;166:105470. doi: 10.1016/j.phrs.2021.105470. Epub 2021 Jan 30. [Article]
ChemSpider
2990
BindingDB
50206334
ChEBI
77986
ChEMBL
CHEMBL365739
ZINC
ZINC000100014654

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.53 mg/mLALOGPS
logP3.8ALOGPS
logP4.24Chemaxon
logS-2.8ALOGPS
Physiological Charge1Chemaxon
Hydrogen Acceptor Count0Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area0 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity63.97 m3·mol-1Chemaxon
Polarizability22.85 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at October 11, 2022 15:49 / Updated at December 13, 2022 10:46