5'-AMP-activated protein kinase subunit gamma-1

BE0009988ProteinHumansPRKAG1

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:21680840, PubMed:24563466). It is acted on by 6 drugs in DrugBank.

Gene name
PRKAG1
UniProtKB entry
P54619Swiss-Prot
Residues / weight
331 residues · 37,579 Da
Also known as
AMPK gamma1 · AMPK subunit gamma-1 · AMPKg

Resolves to

Protein
UniProtP54619UniProt nameAAKG1_HUMAN
Gene
HGNCHGNC:9385NCBI Gene5571GeneCardsPRKAG1
Pharmacology
KEGGhsa:5571
Structure
PDB2UV4PDB2UV5PDB2UV6
Drugs

What you can answer from here — as of May 20, 2020

6DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5'-AMP-activated protein kinase subunit gamma-1, how selective are they, and which programs against it are still in active trials?

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