Angiopoietin-2

BE0010028ProteinHumansANGPT2

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). It is acted on by 7 drugs in DrugBank.

Gene name
ANGPT2
UniProtKB entry
O15123Swiss-Prot
Cellular location
Secreted
Residues / weight
496 residues · 56,919 Da
Also known as
ANG-2

Resolves to

Protein
UniProtO15123UniProt nameANGP2_HUMAN
Gene
HGNCHGNC:485NCBI Gene285GeneCardsANGPT2
Pharmacology
KEGGhsa:285
Structure
PDB1Z3SPDB1Z3UPDB2GY7
Drugs

What you can answer from here — as of December 24, 2020

7DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Angiopoietin-2, how selective are they, and which programs against it are still in active trials?

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