Leucyl-cystinyl aminopeptidase

BE0010031ProteinHumansLNPEP

Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. It is acted on by 1 drug in DrugBank.

Gene name
LNPEP
UniProtKB entry
Q9UIQ6Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,025 residues · 117,348 Da
Also known as
3.4.11.3 · Cystinyl aminopeptidase · Insulin-regulated membrane aminopeptidase · Insulin-responsive aminopeptidase · IRAP

Resolves to

Protein
UniProtQ9UIQ6UniProt nameLCAP_HUMAN
Gene
HGNCHGNC:6656NCBI Gene4012GeneCardsLNPEP
Pharmacology
IUPHAR/GtoPdb1570KEGGhsa:4012
Structure
PDB4P8QPDB4PJ6PDB4Z7I
Drugs

What you can answer from here — as of February 11, 2021

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Leucyl-cystinyl aminopeptidase, how selective are they, and which programs against it are still in active trials?

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