Serine/threonine-protein kinase ATR

BE0010060ProteinHumansATR

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551,... It is acted on by 7 drugs in DrugBank.

Gene name
ATR
UniProtKB entry
Q13535Swiss-Prot
Cellular location
Nucleus
Residues / weight
2,644 residues · 301,364 Da
Also known as
2.7.11.1 · Ataxia telangiectasia and Rad3-related protein · FRAP-related protein 1 · FRP1

Resolves to

Protein
UniProtQ13535UniProt nameATR_HUMAN
Gene
HGNCHGNC:882NCBI Gene545GeneCardsATR
Pharmacology
IUPHAR/GtoPdb1935KEGGhsa:545
Structure
PDB5YZ0PDB9L40PDB9L43
Drugs

What you can answer from here — as of May 07, 2021

7DrugsApproved to experimental, with action, bond type and pharmacological action
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10Clinical trialsTrials of drugs acting on it, by phase and status
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13GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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74+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Serine/threonine-protein kinase ATR, and which indications are they being tested in?

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