Deacylase AADAC

BE0010087ProteinHumansAADAC

Catalyzes the hydrolysis of ester and amide bonds and is largely involved in prodrugs activation, xenobiotic detoxification or toxicity, and, in some contexts, lipid and indole metabolism (PubMed:17936933, PubMed:18034159, PubMed:19339378, PubMed:2043131, PubMed:21856291, PubMed:22207054, PubMed:22415931, PubMed:23542347,... It is acted on by 3 drugs in DrugBank.

Gene name
AADAC
UniProtKB entry
P22760Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
399 residues · 45,733 Da
Also known as
3.-.-.- · Acetylesterase AADAC · Arylacetamide deacetylase · Arylalkyl acylamidase AADAC · DAC

Resolves to

Protein
UniProtP22760UniProt nameAAAD_HUMAN
Gene
HGNCHGNC:17NCBI Gene13GeneCardsAADAC
Pharmacology
KEGGhsa:13
Drugs

What you can answer from here — as of September 08, 2026

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Deacylase AADAC, how selective are they, and which programs against it are still in active trials?

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