Signal transducer and activator of transcription 1-alpha/beta

BE0010099ProteinHumansSTAT1

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:12764129, PubMed:12855578, PubMed:15322115, PubMed:23940278, PubMed:34508746, PubMed:35568036, PubMed:9724754, PubMed:32814877). It is acted on by 1 drug in DrugBank.

Gene name
STAT1
UniProtKB entry
P42224Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
750 residues · 87,334 Da
Also known as
Transcription factor ISGF-3 components p91/p84

Resolves to

Protein
UniProtP42224UniProt nameSTAT1_HUMAN
Gene
HGNCHGNC:11362NCBI Gene6772GeneCardsSTAT1
Pharmacology
IUPHAR/GtoPdb3339KEGGhsa:6772
Structure
PDB1BF5PDB1YVLPDB2KA6
Drugs

What you can answer from here — as of October 27, 2021

1DrugApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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46GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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63+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Signal transducer and activator of transcription 1-alpha/beta, and which indications are they being tested in?

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