Dual specificity mitogen-activated protein kinase kinase 4

BE0010122ProteinHumansMAP2K4

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. It is acted on by 2 drugs in DrugBank.

Gene name
MAP2K4
UniProtKB entry
P45985Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
399 residues · 44,287 Da
Also known as
2.7.12.2 · c-Jun N-terminal kinase kinase 1 · JNK-activating kinase 1 · JNKK · JNKK1

Resolves to

Protein
UniProtP45985UniProt nameMP2K4_HUMAN
Gene
HGNCHGNC:6844NCBI Gene6416GeneCardsMAP2K4
Pharmacology
IUPHAR/GtoPdb2065KEGGhsa:6416
Structure
PDB3ALNPDB3ALOPDB3VUT
Drugs

What you can answer from here — as of November 09, 2021

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
11GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
28+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Dual specificity mitogen-activated protein kinase kinase 4, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In