Elongation factor 1-alpha 2

BE0010196ProteinHumansEEF1A2

Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. It is acted on by 1 drug in DrugBank.

Gene name
EEF1A2
UniProtKB entry
Q05639Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
463 residues · 50,470 Da
Also known as
3.6.5.- · eEF1A-2 · EEF1AL · EF-1-alpha-2 · Eukaryotic elongation factor 1 A-2

Resolves to

Protein
UniProtQ05639UniProt nameEF1A2_HUMAN
Gene
HGNCHGNC:3192NCBI Gene1917GeneCardsEEF1A2
Pharmacology
KEGGhsa:1917
Structure
PDB3C5JPDB8B6Z
Drugs

What you can answer from here — as of August 08, 2022

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Elongation factor 1-alpha 2, and which indications are they being tested in?

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