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- Mechanism
- Curator reviewed · 6 references
Plitidepsin has antineoplastic activity which stems from plitidepsin's ability to inhibit cell growth and induce apoptosis. Plitidepsin's primary intracellular target is the eukaryotic elongation factor 1A2 (eEF1A2). It also inhibits the growth and induces apoptosis in MOLT-4 cells by inhibiting VEGF secretion, which blocks the VEGF/VEGFR-1 autocrine loop that is required for the growth of the MOLT-4 cells.
Through inhibition of eEF1A, plitidepsin also demonstrated antiviral activity against SARS-CoV-2.
The exact mechanism of action is not fully understood and plitidepsin may have multiple modes of action.
- Primary indication
- Intended for the treatment of various forms of cancer.Curator reviewed
- Formula / weight
- C57H87N7O15 · 1110.357 g/mol (avg)
- Also known as
- Dehydrodidemnin B
- Code names
- NSC638719
Resolves to
UUSZLLQJYRSZIS-LXNNNBEUSA-NSMILES[H][C@@]12CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)C(=O)[C@@H](OC(=O)C[C@H](O)[C@]([H])(NC(=O)[C@@H](NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]1CCCN1C(=O)C(C)=O)[C@@H](C)OC(=O)[C@H](CC1=CC=C(OC)C=C1)N(C)C2=O)[C@@H](C)CC)C(C)CWhat you can answer from here — as of October 01, 2026
Which drugs share a target with Plitidepsin, and which of those have an active Phase 3 trial?
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