DNA primase small subunit

BE0010216ProteinHumansPRIM1

Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA... It is acted on by 1 drug in DrugBank.

Gene name
PRIM1
UniProtKB entry
P49642Swiss-Prot
Residues / weight
420 residues · 49,902 Da
Also known as
2.7.7.102 · DNA primase 49 kDa subunit · p49

Resolves to

Protein
UniProtP49642UniProt namePRI1_HUMAN
Gene
HGNCHGNC:9369NCBI Gene5557GeneCardsPRIM1
Pharmacology
KEGGhsa:5557
Structure
PDB4BPUPDB4BPWPDB4BPX
Drugs

What you can answer from here — as of April 12, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA primase small subunit, how selective are they, and which programs against it are still in active trials?

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