Neurogenic locus notch homolog protein 1

BE0010326ProteinHumansNOTCH1

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It is acted on by 3 drugs in DrugBank.

Gene name
NOTCH1
UniProtKB entry
P46531Swiss-Prot
Cellular location
Cell membrane
Residues / weight
2,555 residues · 272,502 Da
Also known as
hN1 · Notch 1 · TAN1 · Translocation-associated notch protein TAN-1

Resolves to

Protein
UniProtP46531UniProt nameNOTC1_HUMAN
Gene
HGNCHGNC:7881NCBI Gene4851GeneCardsNOTCH1
Pharmacology
IUPHAR/GtoPdb2861KEGGhsa:4851
Structure
PDB1PB5PDB1TOZPDB1YYH
Drugs

What you can answer from here — as of October 31, 2023

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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8Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Neurogenic locus notch homolog protein 1, and which indications are they being tested in?

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