Cytoglobin

BE0010408ProteinHumansCYGB

Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability (PubMed:11893755, PubMed:12359339, PubMed:15165856, PubMed:19147491, PubMed:20511233, PubMed:28393874, PubMed:28671819, PubMed:29128400,... It is acted on by 1 drug in DrugBank.

Gene name
CYGB
UniProtKB entry
Q8WWM9Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
190 residues · 21,404 Da
Also known as
HGb · Histoglobin · Nitric oxygen dioxygenase CYGB · Nitrite reductase CYGB · NOD

Resolves to

Protein
UniProtQ8WWM9UniProt nameCYGB_HUMAN
Gene
HGNCHGNC:16505NCBI Gene114757GeneCardsCYGB
Pharmacology
KEGGhsa:114757
Structure
PDB1UMOPDB1URVPDB1URY
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Cytoglobin, how selective are they, and which programs against it are still in active trials?

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