This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Nitrite
- DrugBank Accession Number
- DB12529
- Background
Nitrite is under investigation for the treatment of Heart Failure.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Nitrite (DB12529)
- Weight
- Average: 46.0055
Monoisotopic: 45.992903249 - Chemical Formula
- NO2
- Synonyms
- Nitrite anion
- Nitrite ion
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as non-metal nitrites. These are inorganic non-metallic compounds containing a nitrite as its largest oxoanion.
- Kingdom
- Inorganic compounds
- Super Class
- Homogeneous non-metal compounds
- Class
- Non-metal oxoanionic compounds
- Sub Class
- Non-metal nitrites
- Direct Parent
- Non-metal nitrites
- Alternative Parents
- Inorganic nitrites / Inorganic oxides
- Substituents
- Inorganic nitrite / Inorganic oxide / Non-metal nitrite
- Molecular Framework
- Not Available
- External Descriptors
- monovalent inorganic anion, nitrogen oxoanion, reactive nitrogen species (CHEBI:16301) / an anion (NITRITE)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- J39976L608
- CAS number
- 14797-65-0
- InChI Key
- IOVCWXUNBOPUCH-UHFFFAOYSA-M
- InChI
- InChI=1S/HNO2/c2-1-3/h(H,2,3)/p-1
- IUPAC Name
- nitrite
- SMILES
- [O-]N=O
References
- General References
- Not Available
- External Links
- PDB Entries
- 1as6 / 1as8 / 1fdi / 1j9q / 1j9r / 1j9s / 1j9t / 1kbv / 1l9o / 1l9p … show 166 more
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Unknown Status Not Available Heart Failure 1 somestatus stop reason just information to hide 4 Completed Prevention Mountain Sickness 1 somestatus stop reason just information to hide 2 Completed Treatment Cardiovascular Disease (CVD) / Exercise Intolerance / Heart Failure With Preserved Ejection Fraction (HFpEF) / Pulmonary Hypertension (PH) 1 somestatus stop reason just information to hide 2 Completed Treatment Heart Failure 2 somestatus stop reason just information to hide 2 Completed Treatment Heart Failure, Diastolic / Pulmonary Hypertension (PH) 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 0.17 Chemaxon pKa (Strongest Basic) -3.5 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 52.49 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 7.6 m3·mol-1 Chemaxon Polarizability 2.44 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 109.07225 predictedDeepCCS 1.0 (2019) [M+H]+ 110.86815 predictedDeepCCS 1.0 (2019) [M+Na]+ 117.82373 predictedDeepCCS 1.0 (2019)
Drug created at October 20, 2016 22:44 / Updated at June 12, 2020 16:53