GTPase NRas

BE0010426ProteinHumansNRAS

Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:30712867). It is acted on by 3 drugs in DrugBank.

Gene name
NRAS
UniProtKB entry
P01111Swiss-Prot
Cellular location
Cell membrane
Residues / weight
189 residues · 21,229 Da
Also known as
3.6.5.2 · HRAS1 · Transforming protein N-Ras

Resolves to

Protein
UniProtP01111UniProt nameRASN_HUMAN
Gene
HGNCHGNC:7989NCBI Gene4893GeneCardsNRAS
Pharmacology
IUPHAR/GtoPdb2823KEGGhsa:4893
Structure
PDB2N9CPDB3CONPDB5UHV
Drugs

What you can answer from here — as of October 31, 2023

3DrugsApproved to experimental, with action, bond type and pharmacological action
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41Clinical trialsTrials of drugs acting on it, by phase and status
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which approved drugs act on GTPase NRas, how selective are they, and which programs against it are still in active trials?

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