Myeloid differentiation primary response protein MyD88

BE0010440ProteinHumansMYD88

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575, PubMed:33718825, PubMed:37971847). It is acted on by 1 drug in DrugBank.

Gene name
MYD88
UniProtKB entry
Q99836Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
296 residues · 33,233 Da

Resolves to

Protein
UniProtQ99836UniProt nameMYD88_HUMAN
Gene
HGNCHGNC:7562NCBI Gene4615GeneCardsMYD88
Pharmacology
KEGGhsa:4615
Structure
PDB2JS7PDB2Z5VPDB3MOP
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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9Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Myeloid differentiation primary response protein MyD88, how selective are they, and which programs against it are still in active trials?

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