Povidone-iodine

Identification

Name
Povidone-iodine
Accession Number
DB06812
Description

Povidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis. This unique complex was discovered in 1955 at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski. During in vitro testing to demonstrate anti-bacterial activity it was found that the complex was less toxic in mice than tincture of iodine. Human clinical trials showed the product to be superior to other iodine formulations. Povidone-iodine was immediately marketed, and has since become the universally preferred iodine antiseptic.

Type
Small Molecule
Groups
Approved
Synonyms
  • Iodopovidone
  • Povidone iodine
  • PVP-I

Pharmacology

Indication

For topical application in the treatment and prevention of infection in wounds.

Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics

Povidone iodine is a kind of iodine disinfectant which directly cause in vivo protein denaturation, precipitation of bacteria, and further resulting in the death of pathogenic microorganisms. Therefore, it is effective in disinfection and sterilization. It can kill viruses, bacteria, spores, fungi, and protozoa with low toxicity to human. Povidone-iodine aqueous solution has strong pharmacological activity against Staphylococcus aureus, Neisseria gonorrhoeae, Pseudomonas aeruginosa, syphilis, hepatitis B virus, HIV, and Trichomonas vaginalis. Povidone iodine gel is a gynecological topical semi-mobile colloidal agent made by povidone iodine and hydrophilic matrix. It is a system for maintaining its sustained release. Owing to the continuous release of free iodine, it can enable the skin and mucous membranes to maintain a certain effective concentration of iodine for killing bacteria. It is mainly used for gynecological vaginal infection. It exerted its effect through being miscible with vaginal secretions and further killing the inside pathogenic microorganisms, and thus blocking the spread of sexually transmitted diseases and invasion, as well as treating other infected vaginal diseases caused by other kinds of bacteria.

Published reports on the in vitro antimicrobial efficacy of iodophors demonstrate that iodophors are bactericidal, mycobactericidal, and virucidal but can require prolonged contact times to kill certain fungi and bacterial spores. Three brands of povidone-iodine solution have demonstrated more rapid kill (seconds to minutes) of S. aureus and M. chelonae at a 1:100 dilution than did the stock solution. The virucidal activity of 75–150 ppm available iodine was demonstrated against seven viruses. Other investigators have questioned the efficacy of iodophors against poliovirus in the presence of organic matter and rotavirus in distilled or tapwater. Manufacturers' data demonstrate that commercial iodophors are not sporicidal, but they are tuberculocidal, fungicidal, virucidal, and bactericidal at their recommended use-dilution.

Mechanism of action

Povidone-iodine is called iodophore which means povidone acts as a carrier of iodine. Iodine is considered as the active moiety that mediates microbicidal actions. When released from the complex, free iodine (I2) penetrates the cell wall of microorganisms quickly, and the lethal effects are believed to result from disruption of protein and nucleic acid structure and synthesis. While the full mechanism of action is not fully elucidated, iodine is thought to inhibit vital bacterial cellular mechanisms and structures, and oxidizes nucleotides fatty or amino acids in bacterial cell membranes 1. Additionally, free iodine disrupts the function of the cytosolic enzymes involved in the respiratory chain, causing them to become denatured and deactivated 1. In vitro evidence suggests that iodine also counteracts inflammation elicited by both pathogens and the host response via multifactorial effects. In hosts, povidone-iodine was demonstrated to modulate the redox potential, inhibit the release of inflammatory mediators such as TNF-α and β-galactosidase, inhibit metalloproteinase production, and potentiate the healing signals from pro-inflammatory cytokines by activation of monocytes, T-lymphocytes, and macrophages, in vitro 1.

Absorption

Povidone-Iodine is intended for topical application and is not absorbed.

Volume of distribution

Povidone-Iodine is intended for topical application and has no volume of distribution.

Protein binding

To be used topical. No plasma protein binding reported.

Metabolism

Povidone-Iodine is not absorbed or metabolized.

Route of elimination

Povidone-Iodine is intended for topical application and is not eliminated.

Half-life

Povidone-Iodine is intended for topical application and is not eliminated.

Clearance

Povidone-Iodine is intended for topical application and is not eliminated.

Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity

ORAL (LD50): Acute: 8000 mg/kg [Rat]. 8100 mg/kg [Mouse]

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Active Moieties
NameKindUNIICASInChI Key
Iodineunknown9679TC07X47553-56-2PNDPGZBMCMUPRI-UHFFFAOYSA-N
PovidoneunknownFZ989GH94E9003-39-8Not applicable
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
BetadineSolution5 mg/1mLOphthalmicALCON LABORATORIES, INC.2000-04-01Not applicableUS flag
BetadineSolution5 mg/1mLOphthalmicRebel Distributors2000-04-01Not applicableUS flag
Douche Tray 1%KitTopicalAllegiance Healthcare Corporation1993-12-311999-07-08Canada flag
Irrigation Tray 10% KitLiquidTopicalBaxter Laboratories1991-12-311999-08-10Canada flag
Irrigation Tray W Pvp-I Prep Pad 1%LiquidTopicalBaxter Laboratories1992-12-311999-08-10Canada flag
Urethral Cath Tray W Iodphor Pvp Pad 1%LiquidTopicalBaxter Laboratories1992-12-311999-08-10Canada flag
Additional Data Available
  • Application Number
    Application Number
    Available for Purchase

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code
    Available for Purchase

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
3-in-1 First Aid Povidone-Iodine SwabLiquid10 mg/1mLTopicalSwabplus Inc.2003-03-012013-01-30US flag
3M Skin and Nasal AntisepticSolution5 mg/1mLTopical3M Company2009-07-01Not applicableUS flag
4046 First Aid KitKit10 mg/1mLTopicalHoneywell Safety Products USA, Inc2018-11-212019-10-18US flag
Acu Dyne OintmentOintmentTopicalAcme United Corporation1977-12-311997-05-30Canada flag
Acu Dyne Prep Soln LiqLiquidTopicalAcme United Corporation1977-12-311997-05-30Canada flag
Acu Dyne Skin CleanserLiquidTopicalAcme United Corporation1976-12-311997-05-30Canada flag
Acu Dyne Swab StickStickTopicalAcme United Corporation1977-12-311997-05-30Canada flag
Acudyne Prep SolutionSolutionTopicalAcme United Corporation1976-12-311997-05-30Canada flag
Acudyne Prep Swab F420SwabTopicalAcme United Corporation1973-12-311997-05-30Canada flag
Alpha OneGel10 mg/1mLTopicalAOSS Medical Supply, Inc.2019-10-24Not applicableUS flag
Additional Data Available
  • Application Number
    Application Number
    Available for Purchase

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code
    Available for Purchase

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

    Learn more
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
3-Step First Aid KitPovidone-iodine (100 mg/10mL) + Benzalkonium chloride (11 mg/10mL) + Lidocaine hydrochloride (100 mg/10mL)KitTopicalSwabplus Inc.2003-03-01Not applicableUS flag
4042 First Aid KitPovidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-212019-10-18US flag
4044 First Aid KitPovidone-iodine (10 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-212019-10-18US flag
4045 First Aid KitPovidone-iodine (10 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-212019-10-18US flag
4050 First Aid KitPovidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-212019-10-18US flag
4064 First Aid KitPovidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-212019-10-18US flag
4065 First Aid KitPovidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-21Not applicableUS flag
4066 First Aid KitPovidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-21Not applicableUS flag
4067 First Aid KitPovidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-21Not applicableUS flag
4078 First Aid KitPovidone-iodine (10 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (0.5 g/100g)KitTopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
4042 First Aid KitPovidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-212019-10-18US flag
4044 First Aid KitPovidone-iodine (10 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-212019-10-18US flag
4045 First Aid KitPovidone-iodine (10 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-212019-10-18US flag
4046 First Aid KitPovidone-iodine (10 mg/1mL)KitTopicalHoneywell Safety Products USA, Inc2018-11-212019-10-18US flag
4050 First Aid KitPovidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-212019-10-18US flag
4064 First Aid KitPovidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-212019-10-18US flag
4065 First Aid KitPovidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-21Not applicableUS flag
4066 First Aid KitPovidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-21Not applicableUS flag
4067 First Aid KitPovidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-21Not applicableUS flag
4078 First Aid KitPovidone-iodine (10 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (0.5 g/100g)KitTopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag

Categories

ATC Codes
G01AX11 — Povidone-iodineR02AA15 — Povidone-iodineD08AG02 — Povidone-iodineD09AA09 — Povidone-iodineS01AX18 — Povidone-iodineD11AC06 — Povidone-iodine
Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
85H0HZU99M
CAS number
25655-41-8
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
  1. Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon JK, Wa CTC, Villa MA: Povidone iodine in wound healing: A review of current concepts and practices. Int J Surg. 2017 Aug;44:260-268. doi: 10.1016/j.ijsu.2017.06.073. Epub 2017 Jun 23. [PubMed:28648795]
  2. The efficacy and risks of using povidone-iodine irrigation to prevent surgical site infection: an evidence-based review [Link]
  3. Iodophore activity, CDC [Link]
KEGG Drug
D00863
KEGG Compound
C08043
PubChem Substance
347910372
RxNav
8611
ChEBI
8347
ChEMBL
CHEMBL1201724
Wikipedia
Povidone-iodine
AHFS Codes
  • 40:36.00 — Irrigating Solutions
  • 84:04.92 — Miscellaneous Local Anti-infectives
MSDS
Download (47.9 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Active Not RecruitingPreventionArrhythmia / Heart Failure1
4Active Not RecruitingPreventionHospitalizations / Infection1
4Active Not RecruitingPreventionSurgical Site Infections1
4CompletedOtherStrabismus1
4CompletedOtherSurgical Preparation of the Vagina1
4CompletedPreventionBacteraemia Post Debridement1
4CompletedPreventionBacteremia1
4CompletedPreventionHand Hygiene1
4CompletedPreventionOral Health1
4CompletedPreventionPostpartum Endometritis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LiquidTopical10 mg/1mL
SolutionTopical5 mg/1mL
KitOphthalmic; Oral; Respiratory (inhalation); Topical
KitOphthalmic; Respiratory (inhalation); Topical
KitRespiratory (inhalation); Topical
KitOphthalmic; Topical
KitOral; Respiratory (inhalation); Topical
KitIrrigation; Ophthalmic; Topical
KitIrrigation; Oral; Respiratory (inhalation); Topical
KitIrrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical
StickTopical
SolutionTopical7.5 mg/100mL
SwabTopical0.1 mg/1mL
DoucheVaginal10 g/100g
OintmentTopical10 mg/1g
LiquidTopical10 1/100g
SolutionTopical8.1 g/100g
EmulsionTopical75 mg/1mL
Kit; liquidIntravenous
LiquidIntravenous
DoucheVaginal1 g/25ml
SolutionVaginal0.625 %
Gel10 g/100g
RinseOral7.5 %
SolutionTopical50 mg/1mL
SolutionTopical
KitVaginal0.3 g/100mL
LotionTopical10 % w/v
ClothTopical10 %
CreamTopical5 %
CreamTopical5 g/100g
DoucheVaginal10 g/100ml
Gel10 %
GelVaginal10 %
MouthwashOral1 %
Solution10 %
SolutionCutaneous10 g/100ml
SolutionOphthalmic5 mg/1mL
SolutionVaginal10 %
SprayCutaneous5 %
SprayTopical.05 mL/1mL
SprayTopical.5 mg/1mL
TabletVaginal0.2 G
AerosolTopical
CreamTopical5 % w/w
OintmentTopical10 %w/w
LiquidTopical10 % w/v
CreamTopical0.05 mg/1mL
Aerosol, sprayTopical.05 mg/1mL
PowderTopical2.5 % w/w
LiquidTopical10 %w/v
LiquidVaginal10 %w/v
SolutionOral.05 mg/1mL
MouthwashOral1 %w/v
RinseOral
Injection, solution2 g/100mL
ShampooTopical
DressingTopical
SwabTopical.01 mL/1
SprayOral0.45 %w/v
DoucheVaginal
GelVaginal
GelTopical; Vaginal10 %w/w
SuppositoryVaginal
SolutionOral7.5 g/100ml
GelTopical100 mg/g
SprayTopical25 mg/g
GelVaginal1 %
SuppositoryVaginal200 mg
DressingTopical300 mg
KitInfiltration; Intra-articular; Intralesional; Intramuscular; Perineural; Topical
SolutionTopical10 g/100mL
SolutionTopical7.5 g/100mL
SolutionTopical3.24 g/100ml
GelTopical10 %W/W
OintmentTopical70 g
SuppositoryVaginal0.2 gr
KitEpidural; Infiltration; Topical
SolutionTopical50 g
SolutionTopical50 %
Solution7.5 %
SolutionTopical7.5 %
OintmentTopical10 % w/v
KitEpidural; Intra-articular; Intramuscular; Topical
LiquidSubcutaneous
Liquid; ointmentIntravenous; Topical
Kit; liquid; ointmentInfiltration; Parenteral; Subcutaneous; Topical
PatchTopical100 mg/1
SwabTopical
GelTopical9.7 g/1mL
SolutionTopical9.5 g/1mL
SolutionTopical7.86 g/1mL
OintmentTopical10 g/100g
KitInfiltration; Intramuscular; Intravenous; Topical
KitEpidural; Infiltration; Intramuscular; Intravenous; Topical
MouthwashOral7.5 %w/v
KitEpidural; Infiltration; Intracaudal; Subcutaneous; Topical
KitIntramuscular; Intravenous; Topical
KitTopical
SwabTopical
SwabTopical10 g/100g
SwabTopical7.5 g/100g
GelTopical1.2 mL/100mL
LiquidTopical100 mg/7.5mL
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical
KitInfiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical
SpongeTopical
SolutionTopical75 mg/1mL
LiquidExtracorporeal7.7 mg/500mL
KitEpidural; Infiltration
Kit; ointment; solutionInfiltration; Intravenous; Topical
KitVaginal.3 g/100mL
SolutionTopical10 mg/1mL
LiquidTopical100 mg/1mL
LiquidTopical7.5 mg/100mL
SolutionTopical0.01 g/1mL
SolutionTopical1 g/100mL
SwabTopical0.2 g/1
PatchTopical10 g/100g
KitIntra-amniotic
KitTopical
KitOphthalmic; Oral; Topical
SolutionTopical7500 mg/100mL
SolutionVaginal10 g/100mL
SuppositoryVaginal200 mg/1
SolutionTopical1.25 mg/1mL
SolutionTopical2.5 mg/1mL
SprayOral1.25 g/100mL
SolutionTopical1.75 mg/1mL
Liquid; ointmentEpidural; Topical
Solution / dropsOphthalmic5 g/100mL
KitInfiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical
SolutionTopical10 g
SoapTopical3.9 g/100g
ShampooTopical8 g
Solution300 mg/ml
LiquidTopical
SolutionBuccal; Oropharyngeal0.8 g
SolutionTopical8 g
MouthwashOral7 g/100mL
SprayOral450 mg/100mL
SolutionTopical1 g
KitIntravenous; Topical
Solution100 ml
Solution1000 ml
Solution30 ml
RinseOral100 ml
LiquidTopical10 g/100g
GelTopical10 g/100g
SpongeTopical2 g/20g
OintmentTopical100 mg/g
SolutionTopical1.18 g/118mL
SolutionTopical0.75 g/100g
SolutionTopical1 g/100g
LiquidTopical
LiquidTopical1 g/100mL
KitEpidural; Infiltration; Intra-articular; Intramuscular; Topical
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical
LiquidTopical1 mg/10mL
OintmentTopical100 mg/1g
ClothTopical100 mg/1mL
SolutionTopical0.1 g/1
GelTopical10 mg/1mL
KitEpidural; Infiltration; Intra-articular; Intramuscular
SolutionTopical
KitOral; Topical
SpongeTopical10 mg/1mL
SpongeTopical5 mg/1mL
SolutionTopical.25 mL/5mL
Liquid; ointmentSubcutaneous; Topical
IrrigantTopical10 mg/1mL
Kit; ointment; solutionInfiltration; Subcutaneous; Topical
SolutionTopical10 % w/v
KitEpidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical
LiquidEpidural; Intravenous
KitInfiltration; Intramuscular
OintmentTopical100 g
OintmentTopical20 g
OintmentTopical300 g
OintmentTopical50 g
Solution1 %
OintmentTopical10 % w/w
SolutionTopical10 %
SolutionTopical10 mg/100mL
SolutionTopical10 mL/100mL
SolutionTopical7.5 mg/1mL
SwabTopical10 mg/1mL
LiquidTopical50 mg/1mL
OintmentTopical1 g/10g
SolutionTopical0.10 mg/1mL
SwabTopical1 mL/10mL
SwabTopical10 mL/100mL
SwabTopical100 mg/1mL
SpongeTopical0.1 mg/1mL
SpongeTopical7.5 mg/1mL
GelTopical0.10 g/1mL
OintmentTopical.10 g/1g
SolutionTopical.10 g/1mL
SolutionTopical10 g/100g
SolutionTopical7.5 g/100g
SolutionEpidural; Percutaneous; Topical.10 g/1
SwabTopical10 mg/100mL
ClothTopical10 g/1mL
SwabTopical0.75 mg/1mL
SwabTopical7.5 mg/1mL
SolutionTopical10.34 mg/1mL
SpongeTopical100 mg/1mL
SpongeTopical50 mg/1mL
SpongeTopical90 mg/1mL
Aerosol, sprayTopical0.1 g/1g
OintmentTopical1 g/100g
SolutionTopical9.8 g/100g
SwabPercutaneous0.1 mL/1
SwabTopical0.05 g/1
SolutionTopical0.75 mg/1mL
StickTopical7.5 mg/1mL
GelTopical10 mg/1g
SwabTopical9.43 g/100g
SolutionTopical11 mg/1mL
SolutionTopical0.1 g/1mL
SwabTopical1 mL/100mL
SwabTopical10 mg/1g
SwabPercutaneous10 mL/1
SwabPercutaneous10 mg/1
SwabTopical0.1 mg/1
SwabTopical0.1 mL/1mL
SwabTopical0.10 g/1
SwabTopical100 mg/1
ClothTopical10 mg/1mL
SwabTopical100 mg/1g
SolutionEpidural; Percutaneous; Topical.10 mg/1mL
SolutionEpidural; Percutaneous; Topical0.10 mg/1mL
SpongeTopical100 mg/1g
SwabTopical0.07 g/1
SpongeTopical75 mg/1g
SwabTopical75 mg/1g
SolutionTopical.075 mg/1mL
SolutionPercutaneous0.01 mg/1g
SolutionTopical1 mg/100mL
SolutionTopical1.1 mg/100mL
SolutionTopical100 mg/1mL
GelTopical
ClothTopical10 mg/1
PatchTopical100 mg/1g
LiquidVaginal
LiquidTopical10 %
OintmentTopical
EmulsionTopical7.5 mg/1mL
SpongeTopical
SwabTopical.10 g/1g
StickTopical10 mg/1mL
SolutionTopical10 %w/v
SolutionTopical0.006 g/0.6mL
OintmentTopical10 %
SolutionTopical0.1 g/100mL
SolutionTopical0.75 g/100mL
SolutionTopical8 mL/100mL
SolutionTopical7.5 mg/1
SwabTopical0.9 g/100mL
SwabTopical0.9 mg/100mL
SwabTopical1 g/100mL
DoucheVaginal0.30 mL/100mL
KitEpidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical
LiquidTopical5 mg/1mL
SolutionTopical9 mg/1mL
SolutionTopical15 mg/1mL
SolutionTopical0.75 mg/100mL
SolutionTopical0.15 g/100mL
SolutionTopical0.9 g/100mL
LiquidTopical8.64 g/100mL
KitBuccal; Topical
Solution / dropsOphthalmic
KitInfiltration; Topical
LiquidInfiltration; Subcutaneous; Topical
LiquidParenteral; Topical
KitTopical10 mg/1mL
SoapTopical7.5 %
DoucheVaginal4 g/133mL
LiquidTopical10.5 g/100mL
SwabTopical10 mg/1
SwabTopical10 mg/100mg
SolutionCutaneous10 % w/v
SolutionEpidural; Percutaneous; Topical.075 mL/1mL
SolutionEpidural; Percutaneous; Topical.075 L/1L
SolutionTopical.10 mg/1mL
SolutionTopical.075 mL/1mL
SolutionTopical.10 L/1L
LotionTopical10 %W/V
SprayTopical5 %w/w
OintmentTopical5 %w/w
SolutionTopical11 g
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US7066916No2006-06-272024-02-17US flag
US7595021No2009-09-292023-05-12US flag
US7717889No2010-05-182025-02-27US flag
US7935093No2011-05-032027-10-02US flag
US7427574No2008-09-232026-04-25US flag
Additional Data Available
  • Filed On
    Filed On
    Available for Purchase

    The date on which a patent was filed with the relevant government.

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Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on September 14, 2010 10:21 / Updated on December 02, 2020 00:54

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