Povidone-iodine

Identification

Summary

Povidone-iodine is a topical antiseptic agent used for the treatment and prevention of infection in wounds.

Brand Names

Betadine, Kenalog, Marbeta, Marcaine, P-Care M, P-Care MG, P-care, P-care X, Summer's Eve Medicated

Generic Name

Povidone-iodine

DrugBank Accession Number

DB06812

Background

Povidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis. This unique complex was discovered in 1955 at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski. During in vitro testing to demonstrate anti-bacterial activity it was found that the complex was less toxic in mice than tincture of iodine. Human clinical trials showed the product to be superior to other iodine formulations. Povidone-iodine was immediately marketed, and has since become the universally preferred iodine antiseptic.

Type

Small Molecule

Groups

Approved

Synonyms

Iodopovidone
Povidone iodine
Povidone-iodine
Povidone, iodinated
PVP-I

Pharmacology

Indication

For topical application in the treatment and prevention of infection in wounds.

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Associated Conditions

Skin Infections

Associated Therapies

Contraindications & Blackbox Warnings

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Pharmacodynamics

Povidone iodine is a kind of iodine disinfectant which directly cause in vivo protein denaturation, precipitation of bacteria, and further resulting in the death of pathogenic microorganisms. Therefore, it is effective in disinfection and sterilization. It can kill viruses, bacteria, spores, fungi, and protozoa with low toxicity to human. Povidone-iodine aqueous solution has strong pharmacological activity against Staphylococcus aureus, Neisseria gonorrhoeae, Pseudomonas aeruginosa, syphilis, hepatitis B virus, HIV, and Trichomonas vaginalis. Povidone iodine gel is a gynecological topical semi-mobile colloidal agent made by povidone iodine and hydrophilic matrix. It is a system for maintaining its sustained release. Owing to the continuous release of free iodine, it can enable the skin and mucous membranes to maintain a certain effective concentration of iodine for killing bacteria. It is mainly used for gynecological vaginal infection. It exerted its effect through being miscible with vaginal secretions and further killing the inside pathogenic microorganisms, and thus blocking the spread of sexually transmitted diseases and invasion, as well as treating other infected vaginal diseases caused by other kinds of bacteria.

Published reports on the in vitro antimicrobial efficacy of iodophors demonstrate that iodophors are bactericidal, mycobactericidal, and virucidal but can require prolonged contact times to kill certain fungi and bacterial spores. Three brands of povidone-iodine solution have demonstrated more rapid kill (seconds to minutes) of S. aureus and M. chelonae at a 1:100 dilution than did the stock solution. The virucidal activity of 75–150 ppm available iodine was demonstrated against seven viruses. Other investigators have questioned the efficacy of iodophors against poliovirus in the presence of organic matter and rotavirus in distilled or tapwater. Manufacturers' data demonstrate that commercial iodophors are not sporicidal, but they are tuberculocidal, fungicidal, virucidal, and bactericidal at their recommended use-dilution.

Mechanism of action

Povidone-iodine is called iodophore which means povidone acts as a carrier of iodine. Iodine is considered as the active moiety that mediates microbicidal actions. When released from the complex, free iodine (I2) penetrates the cell wall of microorganisms quickly, and the lethal effects are believed to result from disruption of protein and nucleic acid structure and synthesis. While the full mechanism of action is not fully elucidated, iodine is thought to inhibit vital bacterial cellular mechanisms and structures, and oxidizes nucleotides fatty or amino acids in bacterial cell membranes ¹. Additionally, free iodine disrupts the function of the cytosolic enzymes involved in the respiratory chain, causing them to become denatured and deactivated ¹. In vitro evidence suggests that iodine also counteracts inflammation elicited by both pathogens and the host response via multifactorial effects. In hosts, povidone-iodine was demonstrated to modulate the redox potential, inhibit the release of inflammatory mediators such as TNF-α and β-galactosidase, inhibit metalloproteinase production, and potentiate the healing signals from pro-inflammatory cytokines by activation of monocytes, T-lymphocytes, and macrophages, in vitro ¹.

Absorption

Povidone-Iodine is intended for topical application and is not absorbed.

Volume of distribution

Povidone-Iodine is intended for topical application and has no volume of distribution.

Protein binding

To be used topical. No plasma protein binding reported.

Metabolism

Povidone-Iodine is not absorbed or metabolized.

Route of elimination

Povidone-Iodine is intended for topical application and is not eliminated.

Half-life

Povidone-Iodine is intended for topical application and is not eliminated.

Clearance

Povidone-Iodine is intended for topical application and is not eliminated.

Adverse Effects

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Toxicity

ORAL (LD50): Acute: 8000 mg/kg [Rat]. 8100 mg/kg [Mouse]

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions: This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions: No interactions found.

Products

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Active Moieties

Name	Kind	UNII	CAS	InChI Key
Iodine	unknown	9679TC07X4	7553-56-2	PNDPGZBMCMUPRI-UHFFFAOYSA-N
Povidone	unknown	FZ989GH94E	9003-39-8	Not applicable

Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Betadine	Solution	5 mg/1mL	Ophthalmic	Rebel Distributors	2000-04-01	Not applicable
Betadine	Solution	5 mg/1mL	Ophthalmic	ALCON LABORATORIES, INC.	2000-04-01	Not applicable
Douche Tray 1%	Kit	1 %	Topical	Allegiance Healthcare Corporation	1993-12-31	1999-07-08
Irrigation Tray 10% Kit	Liquid	10 % / kit	Topical	Baxter Laboratories	1991-12-31	1999-08-10
Irrigation Tray W Pvp-I Prep Pad 1%	Liquid	1 % / kit	Topical	Baxter Laboratories	1992-12-31	1999-08-10
Urethral Cath Tray W Iodphor Pvp Pad 1%	Liquid	1 % / kit	Topical	Baxter Laboratories	1992-12-31	1999-08-10

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
3-in-1 First Aid Povidone-Iodine Swab	Liquid	10 mg/1mL	Topical	Swabplus Inc.	2003-03-01	2013-01-30
3M Skin and Nasal Antiseptic	Solution	5 mg/1mL	Topical	3M Company	2009-07-01	Not applicable
4046 First Aid Kit	Kit	10 mg/1mL	Topical	Honeywell Safety Products USA, Inc	2018-11-21	2019-10-18
4233 First Aid Kit	Kit; Swab	10 mg/1mL	Topical	Honeywell Safety Products USA, Inc.	2018-09-13	Not applicable
Acu Dyne Ointment	Ointment	10 %	Topical	Acme United Corporation	1977-12-31	1997-05-30
Acu Dyne Prep Soln Liq	Liquid	10 %	Topical	Acme United Corporation	1977-12-31	1997-05-30
Acu Dyne Skin Cleanser	Liquid	7.5 %	Topical	Acme United Corporation	1976-12-31	1997-05-30
Acu Dyne Swab Stick	Stick	10 %	Topical	Acme United Corporation	1977-12-31	1997-05-30
Acudyne Prep Solution	Solution	1 %	Topical	Acme United Corporation	1976-12-31	1997-05-30
Acudyne Prep Swab F420	Swab	1 %	Topical	Acme United Corporation	1973-12-31	1997-05-30

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
3-Step First Aid Kit	Povidone-iodine (100 mg/10mL) + Benzalkonium chloride (11 mg/10mL) + Lidocaine hydrochloride (100 mg/10mL)	Kit	Topical	Swabplus Inc.	2003-03-01	Not applicable
4042 First Aid Kit	Povidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-21	2019-10-18
4044 First Aid Kit	Povidone-iodine (10 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-21	2019-10-18
4045 First Aid Kit	Povidone-iodine (10 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-21	2019-10-18
4050 First Aid Kit	Povidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-21	2019-10-18
4064 First Aid Kit	Povidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)	Cream; Kit; Ointment; Swab	Topical	Honeywell Safety Products USA, Inc	2018-11-21	2019-10-18
4065 First Aid Kit	Povidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)	Cream; Kit; Ointment; Swab	Topical	Honeywell Safety Products USA, Inc	2018-11-21	Not applicable
4066 First Aid Kit	Povidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)	Cream; Kit; Ointment; Swab	Topical	Honeywell Safety Products USA, Inc	2018-11-21	Not applicable
4067 First Aid Kit	Povidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)	Cream; Kit; Ointment; Swab	Topical	Honeywell Safety Products USA, Inc	2018-11-21	Not applicable
4078 First Aid Kit	Povidone-iodine (10 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (0.5 g/100g)	Cream; Kit; Swab	Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
4042 First Aid Kit	Povidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-21	2019-10-18
4044 First Aid Kit	Povidone-iodine (10 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-21	2019-10-18
4045 First Aid Kit	Povidone-iodine (10 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-21	2019-10-18
4046 First Aid Kit	Povidone-iodine (10 mg/1mL)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-21	2019-10-18
4050 First Aid Kit	Povidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-21	2019-10-18
4064 First Aid Kit	Povidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)	Cream; Kit; Ointment; Swab	Topical	Honeywell Safety Products USA, Inc	2018-11-21	2019-10-18
4065 First Aid Kit	Povidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)	Cream; Kit; Ointment; Swab	Topical	Honeywell Safety Products USA, Inc	2018-11-21	Not applicable
4066 First Aid Kit	Povidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)	Cream; Kit; Ointment; Swab	Topical	Honeywell Safety Products USA, Inc	2018-11-21	Not applicable
4067 First Aid Kit	Povidone-iodine (10 mg/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g)	Cream; Kit; Ointment; Swab	Topical	Honeywell Safety Products USA, Inc	2018-11-21	Not applicable
4078 First Aid Kit	Povidone-iodine (10 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (0.5 g/100g)	Cream; Kit; Swab	Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable

Chemical Identifiers

UNII: 85H0HZU99M
CAS number: 25655-41-8

References

General References

Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon JK, Wa CTC, Villa MA: Povidone iodine in wound healing: A review of current concepts and practices. Int J Surg. 2017 Aug;44:260-268. doi: 10.1016/j.ijsu.2017.06.073. Epub 2017 Jun 23. [Article]
The efficacy and risks of using povidone-iodine irrigation to prevent surgical site infection: an evidence-based review [Link]
Iodophore activity, CDC [Link]

External Links

KEGG Drug: D00863
KEGG Compound: C08043
PubChem Substance: 347910372
RxNav: 8611
ChEBI: 8347
ChEMBL: CHEMBL1201724
Wikipedia: Povidone-iodine

MSDS

Download (47.9 KB)

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Active Not Recruiting	Prevention	Hospitalizations / Infection	1
4	Completed	Other	Strabismus	1
4	Completed	Other	Surgical Preparation of the Vagina	1
4	Completed	Prevention	Arrhythmia / Heart Failure	1
4	Completed	Prevention	Bacteraemia Post Debridement	1
4	Completed	Prevention	Bacteremia	1
4	Completed	Prevention	Breast Neoplasms / Wound Infections	1
4	Completed	Prevention	Cardiac Surgery in Adult Patient	1
4	Completed	Prevention	Coronavirus Disease 2019 (COVID‑19) / Infections, Coronavirus / Mouthwashes / Polymerase Chain Reaction / Saliva / Viral Load	1
4	Completed	Prevention	Hand Hygiene	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Liquid	Topical	10 mg/1mL
Solution	Topical	5 mg/1mL
Cream; kit; ointment; swab	Topical
Cream; kit; swab	Topical
Kit; liquid; swab	Topical
Cream; gel; kit; liquid; ointment; swab	Ophthalmic; Topical
Gel; kit; liquid; swab	Ophthalmic; Topical
Cream; kit; liquid; swab	Ophthalmic; Topical
Cream; kit; liquid; swab	Topical
Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical
Kit	Respiratory (inhalation); Topical
Kit; liquid; ointment; swab	Ophthalmic; Topical
Cream; kit; liquid; ointment; swab	Ophthalmic; Topical
Kit; liquid; ointment; spray; swab; tablet	Ophthalmic; Oral; Topical
Kit; liquid; lozenge; ointment; spray; swab; tablet	Ophthalmic; Oral; Topical
Kit	Ophthalmic; Respiratory (inhalation); Topical
Kit	Oral; Respiratory (inhalation); Topical
Gel; inhalant; kit; liquid; ointment; swab	Ophthalmic; Respiratory (inhalation); Topical
Gel; kit; liquid; ointment; swab	Ophthalmic; Topical
Kit; swab	Topical	10 mg/1mL
Gel; kit; swab	Topical
Inhalant; kit; swab	Respiratory (inhalation); Topical
Kit; liquid; swab	Ophthalmic; Topical
Gel; kit; ointment; swab	Topical
Cream; kit; liquid; ointment; swab	Topical
Gel; kit; liquid; ointment; solution; swab	Ophthalmic; Topical
Kit; liquid; ointment; spray; swab	Ophthalmic; Topical
Cream; kit; liquid; ointment; spray; swab	Ophthalmic; Topical
Gel; kit; liquid; ointment; swab; tablet	Oral; Topical
Irrigant; kit; liquid; swab	Irrigation; Ophthalmic; Topical
Kit	Irrigation; Oral; Respiratory (inhalation); Topical
Kit	Irrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical
Ointment	Topical	10 %
Stick	Topical	10 %
Solution	Topical	1 %
Solution	Topical	7.5 mg/100mL
Swab	Topical	0.1 mg/1mL
Cloth	Topical	10 mg/1g
Douche	Vaginal	10 g/100g
Ointment	Topical	10 mg/1g
Liquid	Topical	10 1/100g
Solution	Topical	8.1 g/100g
Emulsion	Topical	75 mg/1mL
Kit; liquid	Intravenous
Liquid	Intravenous
Solution	Vaginal
Rinse	Oral	7.5 %
Solution	Topical	50 mg/1mL
Solution	Topical
Kit	Vaginal	0.3 g/100mL
Solution	Oral	1 g/100mL
Lotion	Topical
Cloth	Topical	10 %
Cream	Topical	5 %
Douche	Vaginal	10 g/100ml
Gel		10 %
Mouthwash	Oral	1 %
Solution	Cutaneous	10 g/100ml
Solution	Ophthalmic	5 mg/1mL
Solution	Topical	10 %
Solution	Topical	5 %
Solution	Vaginal	10 %
Spray	Cutaneous	5 %
Spray	Topical	.05 mL/1mL
Spray	Topical	5 mg/1mL
Tablet	Vaginal	0.2 G
Aerosol	Topical	5 g / 100 mL
Cream	Topical
Liquid	Topical	10 % w/v
Cream	Topical	0.05 mg/1mL
Aerosol, spray	Topical	.05 mg/1mL
Powder	Topical
Solution	Vaginal	10 % w/v
Liquid	Topical	10 %w/v
Liquid	Vaginal
Solution	Oral	.05 mg/1mL
Swab	Topical	450 mg / pad
Rinse	Oral
Liquid	Topical
Shampoo	Topical	7.5 %
Liquid	Topical	4 g / 100 mL
Liquid	Topical	7.5 g / 100 mL
Dressing	Topical	1 mg / pck
Spray	Oral	0.45 % w/v
Spray	Oral
Douche	Vaginal
Douche	Vaginal	10 %
Gel	Vaginal	10 %
Gel	Vaginal	10 % w/w
Gel	Topical; Vaginal
Suppository	Vaginal	200 mg / sup
Liquid	Topical	10.000 % w/v
Solution	Topical	7.5 g/100ml
Solution	Oral	7.5 g/100ml
Gel	Topical	100 mg/g
Spray	Topical	25 mg/g
Solution	Topical	10 g/100ml
Gel	Vaginal	1 %
Suppository	Vaginal	200 mg
Dressing	Topical	300 mg
Kit	Infiltration; Intra-articular; Intralesional; Intramuscular; Perineural; Topical
Gel	Topical
Suppository	Vaginal	0.2 gr
Kit	Epidural; Infiltration; Topical
Cloth; injection, solution; kit; solution	Epidural; Infiltration; Intra-articular; Intramuscular; Topical
Kit	Epidural; Intra-articular; Intramuscular; Topical
Liquid	Subcutaneous
Liquid; ointment	Intravenous; Topical
Kit; liquid; ointment	Infiltration; Parenteral; Subcutaneous; Topical
Liquid	Nasal	1.25 mg/100mL
Solution	Topical	8.1 g
Patch	Topical	100 mg/1
Swab	Topical	1 %
Gel	Topical	9.7 g/1mL
Solution	Topical	9.5 g/1mL
Solution	Topical	7.86 g/1mL
Injection, solution; kit; solution	Epidural; Infiltration; Intracaudal; Perineural; Topical
Ointment	Topical	10 g/100g
Kit	Infiltration; Intramuscular; Intravenous; Topical
Kit	Epidural; Infiltration; Intramuscular; Intravenous; Topical
Mouthwash	Oral
Kit	Epidural; Infiltration; Intracaudal; Subcutaneous; Topical
Kit	Intramuscular; Intravenous; Topical
Kit	Topical	1 %
Swab	Topical
Swab	Topical	10 g/100g
Swab	Topical	7.5 g/100g
Sponge	Topical	1.1 g/100mL
Gel	Topical	1.2 mL/100mL
Liquid	Topical	100 mg/7.5mL
Kit	Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical
Kit	Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical
Kit	Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical
Kit	Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical
Sponge	Topical	13 %
Sponge	Topical	6.5 %
Liquid	Topical	6.5 %
Sponge	Topical	10 %
Solution	Topical	75 mg/1mL
Liquid	Extracorporeal	7.7 mg/500mL
Kit	Epidural; Infiltration
Kit; ointment; solution	Infiltration; Intravenous; Topical
Ointment	Topical
Kit	Vaginal	.3 g/100mL
Solution	Topical	10 mg/1mL
Liquid	Topical	100 mg/1mL
Liquid	Topical	7.5 mg/100mL
Kit; solution, concentrate	Vaginal	.3 g/100mL
Solution	Topical	0.01 g/1mL
Solution	Topical	1 g/100mL
Swab	Topical	0.2 g/1
Ointment	Topical
Patch	Topical	10 g/100g
Kit	Intra-amniotic
Kit	Topical
Kit	Ophthalmic; Oral; Topical
Solution	Topical	7500 mg/100mL
Solution	Vaginal	10 g/100mL
Suppository	Vaginal	200 mg/1
Solution	Topical	1.25 mg/1mL
Spray	Topical	1.25 g/100mL
Solution	Topical	2.5 mg/1mL
Spray	Oral	1.25 g/100mL
Solution	Topical	1.75 mg/1mL
Liquid; ointment	Epidural; Topical
Kit	Infiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical
Soap	Topical	3.9 g/100g
Solution	Buccal; Oropharyngeal	8 g
Solution
Shampoo	Topical	8 g
Liquid	Topical	10 % / kit
Solution	Topical	8 g
Solution	Topical	1 g
Kit	Intravenous; Topical
Solution		100 ml
Solution		1000 ml
Solution		30 ml
Liquid	Topical	10 g/100g
Gel	Topical	10 g/100g
Sponge	Topical	2 g/20g
Ointment	Topical	100 mg/g
Rinse	Topical
Inhalant; injection, solution; injection, suspension; kit; solution	Epidural; Infiltration; Intra-articular; Intracaudal; Intramuscular; Perineural; Respiratory (inhalation); Topical
Liquid	Topical	75 mg/1mL
Solution	Topical	1.18 g/118mL
Solution	Topical	0.75 g/100g
Solution	Topical	1 g/100g
Swab	Topical	1 g/100g
Liquid	Topical
Liquid	Topical	1 g/100mL
Kit	Epidural; Infiltration; Intra-articular; Intramuscular; Topical
Kit	Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical
Liquid	Topical	1 mg/10mL
Ointment	Topical	100 mg/1g
Cloth	Topical	100 mg/1mL
Solution	Topical	0.1 g/1
Liquid	Topical	1 %
Gel	Topical	10 mg/1mL
Kit	Epidural; Infiltration; Intra-articular; Intramuscular
Kit	Oral; Topical
Ointment	Topical	7.5 g/100g
Liquid	Topical	10 g/100mL
Liquid	Topical	5 g/100mL
Sponge	Topical	10 mg/1mL
Sponge	Topical	5 mg/1mL
Solution	Topical	.25 mL/5mL
Solution	Ophthalmic
Injection, solution; kit; solution	Epidural; Infiltration; Intracaudal; Intravenous; Perineural; Topical
Injection, suspension; kit; solution	Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical
Injection, solution; injection, suspension; kit; solution	Epidural; Infiltration; Intra-articular; Intracaudal; Intralesional; Intramuscular; Intravenous; Perineural; Soft tissue; Topical
Injection, suspension; kit; solution	Intra-articular; Intramuscular; Topical
Injection, solution; injection, suspension; kit; solution	Epidural; Infiltration; Intra-articular; Intracaudal; Intramuscular; Intravenous; Perineural; Topical
Injection; injection, solution; kit; solution	Epidural; Intracaudal; Intravenous; Perineural; Topical
Injection, solution; kit; solution	Epidural; Intracaudal; Intravenous; Perineural; Topical
Liquid; ointment	Subcutaneous; Topical
Irrigant	Topical	10 mg/1mL
Liquid	Infiltration; Subcutaneous; Topical
Kit; ointment; solution	Infiltration; Subcutaneous; Topical
Kit	Epidural; Infiltration; Intra-articular; Intracaudal; Intramuscular; Perineural; Respiratory (inhalation); Topical
Cloth; injection, solution; injection, suspension; kit	Infiltration; Intra-articular; Intramuscular; Topical
Kit	Epidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical
Liquid	Epidural; Intravenous
Kit	Infiltration; Soft tissue; Topical
Kit	Epidural; Infiltration; Intracaudal; Perineural
Kit	Epidural; Infiltration; Intracaudal
Solution	Topical	10 % W/V
Ointment	Topical	100 g
Ointment	Topical	20 g
Ointment	Topical	300 g
Ointment	Topical	50 g
Ointment	Topical	10 % w/w
Solution	Topical	10 mL/100mL
Solution	Topical	7.5 mg/1mL
Swab	Topical	10 mg/1mL
Liquid	Oral	5 mg/1mL
Liquid	Topical	50 mg/1mL
Ointment	Topical	1 g/10g
Ointment	Topical	5 g/100g
Solution	Topical	0.10 mg/1mL
Swab	Topical	1 mL/10mL
Swab	Topical	10 mL/100mL
Swab	Topical	100 mg/1mL
Sponge	Topical	0.1 mg/1mL
Sponge	Topical	7.5 mg/1mL
Gel	Topical	0.10 g/1mL
Ointment	Topical	.10 g/1g
Solution	Topical	.10 g/1mL
Solution	Topical	10 g/100g
Solution	Epidural; Percutaneous; Topical	.10 g/1
Swab	Topical	10 mg/100mL
Cloth	Topical	10 g/1mL
Solution	Topical	7.5 g/100g
Swab	Topical	0.75 mg/1mL
Swab	Topical	7.5 mg/1mL
Solution	Topical	10.34 mg/1mL
Sponge	Topical	100 mg/1mL
Sponge	Topical	50 mg/1mL
Sponge	Topical	90 mg/1mL
Liquid	Topical	1 % / 0.6 mL
Aerosol, spray	Topical	0.1 g/1g
Ointment	Topical	1 g/100g
Solution	Topical	9.8 g/100g
Swab	Percutaneous	0.1 mL/1
Swab	Topical	0.05 g/1
Solution	Topical	0.75 mg/1mL
Stick	Topical	7.5 mg/1mL
Gel	Topical	10 mg/1g
Swab	Topical	9.43 g/100g
Solution	Topical	11 mg/1mL
Solution	Topical	0.1 g/1mL
Swab	Topical	1 mL/100mL
Swab	Topical	10 mg/1g
Swab	Percutaneous	10 mL/1
Swab	Percutaneous	10 mg/1
Swab	Topical	0.1 mg/1
Swab	Topical	0.1 mL/1mL
Swab	Topical	0.10 g/1
Swab	Topical	100 mg/1
Cloth	Topical	10 g/100g
Cloth	Topical	10 mg/1mL
Swab	Topical	100 mg/1g
Solution	Epidural; Percutaneous; Topical	.10 mg/1mL
Solution	Epidural; Percutaneous; Topical	0.10 mg/1mL
Sponge	Topical	100 mg/1g
Solution	Topical	7.5 %
Swab	Topical	0.07 g/1
Sponge	Topical	75 mg/1g
Swab	Topical	75 mg/1g
Solution	Topical	.075 mg/1mL
Solution	Percutaneous	0.01 mg/1g
Liquid	Topical	100 mg/1g
Solution	Topical	1 mg/100mL
Solution	Topical	1.1 mg/100mL
Solution	Topical	100 mg/1mL
Gel	Topical
Cloth	Topical	10 mg/1
Patch	Topical	100 mg/1g
Swab	Topical	0.12 g/1
Swab	Topical	12 g/1
Aerosol	Topical	.5 %
Liquid	Topical	7.5 %
Liquid	Vaginal	10 %
Liquid	Topical	10 %
Ointment	Topical	10 mg / g
Suppository	Vaginal	25 mg / sup
Emulsion	Topical	7.5 mg/1mL
Sponge	Topical
Swab	Topical	.10 g/1g
Stick	Topical	10 mg/1mL
Solution	Topical	10 %w/v
Solution	Topical	0.006 g/0.6mL
Solution	Topical	0.1 g/100mL
Solution	Topical	0.75 g/100mL
Solution	Topical	8 mL/100mL
Solution	Topical	7.5 mg/1
Swab	Topical	0.9 g/100mL
Swab	Topical	0.9 mg/100mL
Swab	Topical	1 g/100mL
Douche	Vaginal	0.30 mL/100mL
Douche; kit	Vaginal	.3 g/100mL
Kit	Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical
Swab	Topical	10 %
Ointment	Topical	5 mg/1g
Liquid	Topical	5 mg/1mL
Solution	Topical	9 mg/1mL
Solution	Topical	15 mg/1mL
Solution	Topical	0.75 mg/100mL
Solution	Topical	0.15 g/100mL
Solution	Topical	0.9 g/100mL
Liquid	Topical	8.64 g/100mL
Kit	Buccal; Topical
Solution / drops	Ophthalmic
Liquid	Topical	.75 %
Kit	Infiltration; Topical
Liquid	Parenteral; Topical
Kit	Topical	10 mg/1mL
Soap	Topical
Douche	Vaginal	4 g/133mL
Liquid	Topical	10.5 g/100mL
Swab	Topical	10 mg/1
Swab	Topical	10 mg/100mg
Solution	Cutaneous
Solution	Epidural; Percutaneous; Topical	.075 mL/1mL
Solution	Epidural; Percutaneous; Topical	.075 L/1L
Solution	Topical	.10 mg/1mL
Solution	Topical	.075 mL/1mL
Solution	Topical	.10 L/1L
Liquid	Topical	1 % / kit
Spray	Topical
Solution	Topical
Insert	Vaginal	200 mg
Ointment	Topical	10 g
Solution	Buccal; Oral	8 g
Solution	Buccal; Oropharyngeal	0.8 g
Solution	Topical	11 g
Solution	Topical	10 g
Mouthwash	Oral	70 mg/1ml
Powder	Topical	2.5 %w/w
Ointment	Topical	10 %w/w
Cream	Topical	5 %w/w
Spray	Oral	450 mg/100ml
Gel		10 %w/w

Prices

Not Available

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US7066916	No	2006-06-27	2024-02-17
US7595021	No	2009-09-29	2023-05-12
US7717889	No	2010-05-18	2025-02-27
US7935093	No	2011-05-03	2027-10-02
US7427574	No	2008-09-23	2026-04-25

Properties

State: Solid
Experimental Properties: Not Available
Predicted Properties: Not Available
Predicted ADMET Features: Not Available

Spectra

Mass Spec (NIST): Not Available
Spectra: Not Available

Drug created at September 14, 2010 16:21 / Updated at May 29, 2023 00:57

Povidone-iodine

Identification

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra