Histone-lysine N-methyltransferase 2A

BE0010441ProteinHumansKMT2A

Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). It is acted on by 2 drugs in DrugBank.

Gene name
KMT2A
UniProtKB entry
Q03164Swiss-Prot
Cellular location
Nucleus
Residues / weight
3,969 residues · 431,760 Da
Also known as
2.1.1.364 · ALL-1 · ALL1 · CXXC-type zinc finger protein 7 · CXXC7

Resolves to

Protein
UniProtQ03164UniProt nameKMT2A_HUMAN
Gene
HGNCHGNC:7132NCBI Gene4297GeneCardsKMT2A
Pharmacology
KEGGhsa:4297
Structure
PDB2AGHPDB2J2SPDB2JYI
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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12Clinical trialsTrials of drugs acting on it, by phase and status
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1GO termFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Histone-lysine N-methyltransferase 2A, and which indications are they being tested in?

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