Dickkopf-related protein 1

BE0010467ProteinHumansDKK1

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). It is acted on by 2 drugs in DrugBank.

Gene name
DKK1
UniProtKB entry
O94907Swiss-Prot
Cellular location
Secreted
Residues / weight
266 residues · 28,671 Da
Also known as
Dickkopf-1 · Dkk-1 · hDkk-1 · SK

Resolves to

Protein
UniProtO94907UniProt nameDKK1_HUMAN
Gene
HGNCHGNC:2891NCBI Gene22943GeneCardsDKK1
Pharmacology
KEGGhsa:22943
Structure
PDB3S2KPDB3S8VPDB3SOQ
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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32GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dickkopf-related protein 1, and which indications are they being tested in?

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