Neurogenic locus notch homolog protein 4

BE0010483ProteinHumansNOTCH4

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. It is acted on by 2 drugs in DrugBank.

Gene name
NOTCH4
UniProtKB entry
Q99466Swiss-Prot
Cellular location
Cell membrane
Residues / weight
2,003 residues · 209,620 Da
Also known as
hNotch4 · INT3 · Notch 4

Resolves to

Protein
UniProtQ99466UniProt nameNOTC4_HUMAN
Gene
HGNCHGNC:7884NCBI Gene4855GeneCardsNOTCH4
Pharmacology
KEGGhsa:4855
Structure
PDB7OR3PDB7OR5PDB7OR7
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Neurogenic locus notch homolog protein 4, and which indications are they being tested in?

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