Mitogen-activated protein kinase kinase kinase 8

BE0010492ProteinHumansMAP3K8

Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF (TNF) during immune responses. It is acted on by 2 drugs in DrugBank.

Gene name
MAP3K8
UniProtKB entry
P41279Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
467 residues · 52,924 Da
Also known as
2.7.11.25 · Cancer Osaka thyroid oncogene · COT · ESTF · Proto-oncogene c-Cot

Resolves to

Protein
UniProtP41279UniProt nameM3K8_HUMAN
Gene
HGNCHGNC:6860NCBI Gene1326GeneCardsMAP3K8
Pharmacology
IUPHAR/GtoPdb2083KEGGhsa:1326
Structure
PDB4Y83PDB4Y85PDB5IU2
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Mitogen-activated protein kinase kinase kinase 8, and which indications are they being tested in?

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