Tilpisertib fosmecarbil

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DB18797InvestigationalSmall molecule

Tilpisertib fosmecarbil: Overview.

Mechanism: Pharmacologically active on Mitogen-activated protein kinase kinase kinase 8
Curator reviewed
Formula / weight: C₃₅H₃₆ClN₈O₇P · 747.15 g/mol (avg)
Code names: GS-5290

Resolves to

Compound

UNIIH1W0G02O9TCAS2567459-64-5

Structure

InChIKeyFPQIBCPWXJSFOQ-ILNPBIMBSA-NSMILESCN1C=CC2=C(C=CC=C2C1=O)[C@H](N(C(=O)OCOP(O)(O)=O)C1=CC2=C(NCC(C)(C)C)C(=CN=C2C(Cl)=C1)C#N)C1=CN(N=N1)C12CC(C1)C2

Targets

P41279MAP3K8

What you can answer from here — as of September 12, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Tilpisertib fosmecarbil, and which of those have an active Phase 3 trial?

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