RAC-gamma serine/threonine-protein kinase

BE0010514ProteinHumansAKT3

AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. It is acted on by 11 drugs in DrugBank.

Gene name
AKT3
UniProtKB entry
Q9Y243Swiss-Prot
Cellular location
Nucleus
Residues / weight
479 residues · 55,774 Da
Also known as
2.7.11.1 · PKB gamma · PKBG · Protein kinase Akt-3 · Protein kinase B gamma

Resolves to

Protein
UniProtQ9Y243UniProt nameAKT3_HUMAN
Gene
HGNCHGNC:393NCBI Gene10000GeneCardsAKT3
Pharmacology
IUPHAR/GtoPdb2286KEGGhsa:10000
Structure
PDB2X18PDB8ZXW
Drugs

What you can answer from here — as of October 31, 2023

11DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on RAC-gamma serine/threonine-protein kinase, how selective are they, and which programs against it are still in active trials?

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