Uprosertib

DB11969InvestigationalSmall molecule

Uprosertib has been used in trials studying the treatment of Cancer, Melanoma, Solid Tumours, Cervical Cancer, and HER2/Neu Negative, among others.

Chemical structure of Uprosertib
Formula / weight
C18H16Cl2F2N4O2 · 429.25 g/mol (avg)
Code names
GSK2141795 · GSK-2141795C

Resolves to

Compound
UNIIZXM835LQ5ECAS1047634-65-0ChEMBLCHEMBL3137336PubChem51042438
Structure
InChIKeyAXTAPYRUEKNRBA-JTQLQIEISA-NSMILESCN1N=CC(Cl)=C1C1=C(Cl)OC(=C1)C(=O)N[C@H](CN)CC1=CC=C(F)C(F)=C1
Targets
Q9Y243AKT3

What you can answer from here — as of August 29, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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10Clinical trialsPhase, status and sponsor resolved per trial
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1+ReferenceStructured and connected to the statements they support
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Which drugs share a target with Uprosertib, and which of those have an active Phase 3 trial?

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