Growth/differentiation factor 15

BE0010537ProteinHumansGDF15

Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite (PubMed:23468844, PubMed:24971956, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886,... It is acted on by 2 drugs in DrugBank.

Gene name
GDF15
UniProtKB entry
Q99988Swiss-Prot
Cellular location
Secreted
Residues / weight
308 residues · 34,140 Da
Also known as
GDF-15 · Macrophage inhibitory cytokine 1 · MIC-1 · MIC1 · NAG-1

Resolves to

Protein
UniProtQ99988UniProt nameGDF15_HUMAN
Gene
HGNCHGNC:30142NCBI Gene9518GeneCardsGDF15
Pharmacology
KEGGhsa:9518
Structure
PDB5VT2PDB5VZ3PDB5VZ4
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Growth/differentiation factor 15, and which indications are they being tested in?

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