Tumor necrosis factor receptor superfamily member 16

BE0010540ProteinHumansNGFR

Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. It is acted on by 3 drugs in DrugBank.

Gene name
NGFR
UniProtKB entry
P08138Swiss-Prot
Cellular location
Cell membrane
Residues / weight
427 residues · 45,183 Da
Also known as
Gp80-LNGFR · Low affinity neurotrophin receptor p75NTR · Low-affinity nerve growth factor receptor · Low-affinity nerve growth factor receptor p75NGFR · Low-affinity nerve growth factor receptor p75NGR

Resolves to

Protein
UniProtP08138UniProt nameTNR16_HUMAN
Gene
HGNCHGNC:7809NCBI Gene4804GeneCardsNGFR
Pharmacology
IUPHAR/GtoPdb1888KEGGhsa:4804
Structure
PDB2N80PDB2N83PDB2N97
Drugs

What you can answer from here — as of October 31, 2023

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tumor necrosis factor receptor superfamily member 16, how selective are they, and which programs against it are still in active trials?

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