Stromal interaction molecule 1

BE0010575ProteinHumansSTIM1

Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159,... It is acted on by 2 drugs in DrugBank.

Gene name
STIM1
UniProtKB entry
Q13586Swiss-Prot
Cellular location
Cell membrane
Residues / weight
685 residues · 77,423 Da
Also known as
GOK

Resolves to

Protein
UniProtQ13586UniProt nameSTIM1_HUMAN
Gene
HGNCHGNC:11386NCBI Gene6786GeneCardsSTIM1
Pharmacology
KEGGhsa:6786
Structure
PDB2K60PDB2MAJPDB2MAK
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
2GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
3+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Stromal interaction molecule 1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In