DNA-binding protein Ikaros

BE0010593ProteinHumansIKZF1

Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). It is acted on by 3 drugs in DrugBank.

Gene name
IKZF1
UniProtKB entry
Q13422Swiss-Prot
Cellular location
Nucleus
Residues / weight
519 residues · 57,528 Da
Also known as
IK1 · IKAROS · Ikaros family zinc finger protein 1 · LYF1 · Lymphoid transcription factor LyF-1

Resolves to

Protein
UniProtQ13422UniProt nameIKZF1_HUMAN
Gene
HGNCHGNC:13176NCBI Gene10320GeneCardsIKZF1
Pharmacology
KEGGhsa:10320
Structure
PDB6H0FPDB8D7ZPDB8D80
Drugs

What you can answer from here — as of October 31, 2023

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA-binding protein Ikaros, how selective are they, and which programs against it are still in active trials?

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